Comparison of Oral Anticoagulant Users with Non-users Admission Laboratory Parameters, Length of Hospital Stay and Outcomes in COVID-19 Infection
Objective: We aimed to investigate the effect of oral anticoagulant (OA) use during coronavirus disease-2019 (COVID-19) on early admission laboratory parameters and/or length of hospital stay in patients receiving chronic OA medication. Materials and Methods: This retrospective study included two g...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Türkiye Acil Tıp Vakfı
2024-08-01
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| Series: | Global Emergency and Critical Care |
| Subjects: | |
| Online Access: | https://globemcc.com/articles/comparison-of-oral-anticoagulant-users-with-non-users-admission-laboratory-parameters-length-of-hospital-stay-and-outcomes-in-covid-19-infection/doi/globecc.galenos.2023.86580 |
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| Summary: | Objective: We aimed to investigate the effect of oral anticoagulant (OA) use during coronavirus disease-2019 (COVID-19) on early admission laboratory parameters and/or length of hospital stay in patients receiving chronic OA medication.
Materials and Methods: This retrospective study included two groups; group 1 (n=62) consisted of OA users, and group 2 (n=75) of age and sex-matched OA non-users at the time of COVID-19 diagnosis. Early admission laboratory measures, numbers of comorbidities, length of hospital stay, and outcomes of patients were recorded and analyzed.
Results: Despite higher comorbidities in group 1, serum C-reactive protein (CRP) and D-dimer levels were significantly lower than group 2 (p<0.05, all). The mortality rate was higher in group 2 but did not reach statistical significance (p>0.05). Regression analysis showed that OA users (compared to OA non-users) had 0.980 and 0.520 times lower serum CRP and D-dimer levels, respectively.
Conclusion: This study showed a beneficial effect of OA use on early admission serum CRP, and D-dimer levels, which are important prognostic predictors of COVID-19. Additionally, OA use is associated with fewer hospital stays for COVID-19 patients. These beneficial effects of OA use might help improve the management of this infection after further studies in this field. |
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| ISSN: | 2822-4078 |