Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies
Aims: To characterize the complex relationships of body mass index (BMI) and triglyceride–glucose index (TyG) with 5-year all-cause mortality in patients with diabetes mellitus and comorbid hypertension. Methods: Overall, 5,728 patients from the 1999–2014 US National Health and Nutrition Examination...
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Elsevier
2025-09-01
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| Series: | Journal of Clinical & Translational Endocrinology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623725000341 |
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| author | Yilu Liu Hongzhao You Yingxuan Zhu Fang Luo Yanyan Zhao Dingyue Zhang Ying Xiao Shijie You Rui Zhang Yingdong Han Jing Li Shouling Wu Jiansong Yuan Shuohua Chen Weixian Yang |
| author_facet | Yilu Liu Hongzhao You Yingxuan Zhu Fang Luo Yanyan Zhao Dingyue Zhang Ying Xiao Shijie You Rui Zhang Yingdong Han Jing Li Shouling Wu Jiansong Yuan Shuohua Chen Weixian Yang |
| author_sort | Yilu Liu |
| collection | DOAJ |
| description | Aims: To characterize the complex relationships of body mass index (BMI) and triglyceride–glucose index (TyG) with 5-year all-cause mortality in patients with diabetes mellitus and comorbid hypertension. Methods: Overall, 5,728 patients from the 1999–2014 US National Health and Nutrition Examination Survey (NHANES) cycles and 3,456 from the 2005–2010 China Kailuan cycles were included. TyG was calculated as the logarithmic product of the fasting triglyceride and glucose concentrations. Results: The prevalence of 5-year all-cause mortality was 8.4 % in the NHANES population and 9.2 % in the Kailuan cohort. TyG mediated the association between BMI and all-cause mortality, being responsible for 38.4 % in the NHANES database and 41.6 % in the Kailuan cohort. Significant multiplicative effects were identified between TyG and BMI, which were closer for patients with high BMI. When stratified by BMI and TyG, high-risk subgroups were identified and had higher risks of all-cause mortality than the intermediate- and low-risk subgroups (both log-rank P < 0.001). Conclusions: TyG mediated a considerable proportion of the effect of BMI on all-cause mortality in patients with diabetes and hypertension. The combination of BMI and TyG could be useful for the risk stratification of all-cause mortality. Measures aimed at weight loss might reduce the all-cause mortality risk associated with insulin resistance. |
| format | Article |
| id | doaj-art-1902a5ecb36b4d4d9df07a4f839f7b2a |
| institution | Kabale University |
| issn | 2214-6237 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj-art-1902a5ecb36b4d4d9df07a4f839f7b2a2025-08-24T05:12:48ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372025-09-014110041610.1016/j.jcte.2025.100416Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studiesYilu Liu0Hongzhao You1Yingxuan Zhu2Fang Luo3Yanyan Zhao4Dingyue Zhang5Ying Xiao6Shijie You7Rui Zhang8Yingdong Han9Jing Li10Shouling Wu11Jiansong Yuan12Shuohua Chen13Weixian Yang14Fuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaFuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaMedical Research and Biometrics Centre, National Centre for Cardiovascular Diseases, Beijing, ChinaFuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaMedical Research and Biometrics Centre, National Centre for Cardiovascular Diseases, Beijing, ChinaDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaFuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaFuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaFuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, ChinaFuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Corresponding authorsat: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167, Beilishi Road, Xicheng District, Beijing 100037, China.Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China; Corresponding authorsat: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167, Beilishi Road, Xicheng District, Beijing 100037, China.Fuwai Hospital and National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Corresponding authorsat: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167, Beilishi Road, Xicheng District, Beijing 100037, China.Aims: To characterize the complex relationships of body mass index (BMI) and triglyceride–glucose index (TyG) with 5-year all-cause mortality in patients with diabetes mellitus and comorbid hypertension. Methods: Overall, 5,728 patients from the 1999–2014 US National Health and Nutrition Examination Survey (NHANES) cycles and 3,456 from the 2005–2010 China Kailuan cycles were included. TyG was calculated as the logarithmic product of the fasting triglyceride and glucose concentrations. Results: The prevalence of 5-year all-cause mortality was 8.4 % in the NHANES population and 9.2 % in the Kailuan cohort. TyG mediated the association between BMI and all-cause mortality, being responsible for 38.4 % in the NHANES database and 41.6 % in the Kailuan cohort. Significant multiplicative effects were identified between TyG and BMI, which were closer for patients with high BMI. When stratified by BMI and TyG, high-risk subgroups were identified and had higher risks of all-cause mortality than the intermediate- and low-risk subgroups (both log-rank P < 0.001). Conclusions: TyG mediated a considerable proportion of the effect of BMI on all-cause mortality in patients with diabetes and hypertension. The combination of BMI and TyG could be useful for the risk stratification of all-cause mortality. Measures aimed at weight loss might reduce the all-cause mortality risk associated with insulin resistance.http://www.sciencedirect.com/science/article/pii/S2214623725000341Diabetes mellitusHypertensionAll-cause mortalityTriglyceride–glucose indexBody mass indexCohort study |
| spellingShingle | Yilu Liu Hongzhao You Yingxuan Zhu Fang Luo Yanyan Zhao Dingyue Zhang Ying Xiao Shijie You Rui Zhang Yingdong Han Jing Li Shouling Wu Jiansong Yuan Shuohua Chen Weixian Yang Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies Journal of Clinical & Translational Endocrinology Diabetes mellitus Hypertension All-cause mortality Triglyceride–glucose index Body mass index Cohort study |
| title | Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies |
| title_full | Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies |
| title_fullStr | Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies |
| title_full_unstemmed | Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies |
| title_short | Relationships of triglyceride–glucose index and body mass index with 5-year all-cause mortality in patients with diabetes and comorbid hypertension: Evidence from two prospective cohort studies |
| title_sort | relationships of triglyceride glucose index and body mass index with 5 year all cause mortality in patients with diabetes and comorbid hypertension evidence from two prospective cohort studies |
| topic | Diabetes mellitus Hypertension All-cause mortality Triglyceride–glucose index Body mass index Cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S2214623725000341 |
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