Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism
Aim of investigation. Complex estimation of endothelial function at non-alcoholic fatty liver disease (NAFLD) in association with early disorders of carbohydrate metabolism, in relation to liver fibrosis severity.Material and methods. Overall 67 patients with metabolic syndrome (MS) in combination t...
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| Language: | Russian |
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Gastro LLC
2014-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1155 |
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| author | L. V. Chesnokova I. M. Petrov Ye. A. Sidorova I. A. Troshina Yu. A. Petrova |
| author_facet | L. V. Chesnokova I. M. Petrov Ye. A. Sidorova I. A. Troshina Yu. A. Petrova |
| author_sort | L. V. Chesnokova |
| collection | DOAJ |
| description | Aim of investigation. Complex estimation of endothelial function at non-alcoholic fatty liver disease (NAFLD) in association with early disorders of carbohydrate metabolism, in relation to liver fibrosis severity.Material and methods. Overall 67 patients with metabolic syndrome (MS) in combination to early carbohydrate metabolism disorders (71,6% women), mean age was 47,5 (42–49 years), body mass index — 34,6 kg/m2 (32,4–38,4 kg/m2) were investigated. In 72% of patients presence of NAFLD at steatosis stage and in 18% —at non-alcoholic steatohepatitis stage was found.Results. In patients with MS in association to early disorders of carbohydrate metabolism liver fibrosis at F1 METAVIR stage was revealed in 25%, at F2 — in 16%, at F3 — in 13% and at F4 — in 1,5% of all cases. Along with increase of fibrosis stage progressive elevation of TNF-α (p=0,0265), IL-6 (p=0,0012) and endothelin-1 (p=0,0137) contents on background of decrease of adiponectin concentration (p=0,0026) and gain of humeral artery diameter after compression (p=0,005) was marked.Conclusions. Presence and severity of liver fibrosis at MS in combination to early disorders of carbohydrate metabolism are related to increase of proinflammatory cytokines, endothelin-1 concentration on a background of reduction of adiponectin contents and decrease of endothelium vasodilation capacity. |
| format | Article |
| id | doaj-art-18ff784d39884b1fae69c247556e813f |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2014-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-18ff784d39884b1fae69c247556e813f2025-02-10T16:14:39ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732014-12-012464550750Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolismL. V. Chesnokova0I. M. Petrov1Ye. A. Sidorova2I. A. Troshina3Yu. A. Petrova4State educational government-financed institution of higher professional education «Tyumen state medical academy», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Tyumen state medical academy», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Tyumen state medical academy», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Tyumen state medical academy», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Tyumen state oil-and-gas university»Aim of investigation. Complex estimation of endothelial function at non-alcoholic fatty liver disease (NAFLD) in association with early disorders of carbohydrate metabolism, in relation to liver fibrosis severity.Material and methods. Overall 67 patients with metabolic syndrome (MS) in combination to early carbohydrate metabolism disorders (71,6% women), mean age was 47,5 (42–49 years), body mass index — 34,6 kg/m2 (32,4–38,4 kg/m2) were investigated. In 72% of patients presence of NAFLD at steatosis stage and in 18% —at non-alcoholic steatohepatitis stage was found.Results. In patients with MS in association to early disorders of carbohydrate metabolism liver fibrosis at F1 METAVIR stage was revealed in 25%, at F2 — in 16%, at F3 — in 13% and at F4 — in 1,5% of all cases. Along with increase of fibrosis stage progressive elevation of TNF-α (p=0,0265), IL-6 (p=0,0012) and endothelin-1 (p=0,0137) contents on background of decrease of adiponectin concentration (p=0,0026) and gain of humeral artery diameter after compression (p=0,005) was marked.Conclusions. Presence and severity of liver fibrosis at MS in combination to early disorders of carbohydrate metabolism are related to increase of proinflammatory cytokines, endothelin-1 concentration on a background of reduction of adiponectin contents and decrease of endothelium vasodilation capacity.https://www.gastro-j.ru/jour/article/view/1155liver fibrosisendothelial dysfunctionmetabolic syndromeearly disorders of carbohydrate metabolism |
| spellingShingle | L. V. Chesnokova I. M. Petrov Ye. A. Sidorova I. A. Troshina Yu. A. Petrova Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism Российский журнал гастроэнтерологии, гепатологии, колопроктологии liver fibrosis endothelial dysfunction metabolic syndrome early disorders of carbohydrate metabolism |
| title | Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism |
| title_full | Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism |
| title_fullStr | Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism |
| title_full_unstemmed | Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism |
| title_short | Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism |
| title_sort | liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism |
| topic | liver fibrosis endothelial dysfunction metabolic syndrome early disorders of carbohydrate metabolism |
| url | https://www.gastro-j.ru/jour/article/view/1155 |
| work_keys_str_mv | AT lvchesnokova liverfibrosisandmarkersofendothelialfunctionatmetabolicsyndromeandearlydisordersofcarbohydratemetabolism AT impetrov liverfibrosisandmarkersofendothelialfunctionatmetabolicsyndromeandearlydisordersofcarbohydratemetabolism AT yeasidorova liverfibrosisandmarkersofendothelialfunctionatmetabolicsyndromeandearlydisordersofcarbohydratemetabolism AT iatroshina liverfibrosisandmarkersofendothelialfunctionatmetabolicsyndromeandearlydisordersofcarbohydratemetabolism AT yuapetrova liverfibrosisandmarkersofendothelialfunctionatmetabolicsyndromeandearlydisordersofcarbohydratemetabolism |