From Bitter to Sweet: a preliminary study towards a patient-friendly Praziquantel dosage form

From Bitter to Sweet: a preliminary study towards a patient-friendly Praziquantel dosage form

Praziquantel (PZQ) is an antihelmintic drug used worldwide against Schistosomiasis, despite its low solubility, bioavailability and the disgusting taste. This research represents a preliminary screening of 6 selected sweeteners in terms of their aptitude to be ground with PZQ, towards the developmen...

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Bibliographic Details
Main Authors: Zanolla, Debora, Bertoni, Serena, Passerini, Nadia, Albertini, Beatrice, Zingone, Guglielmo, Perissutti, Beatrice
Format: Article
Language:English
Published: Académie des sciences 2022-07-01
Series:Comptes Rendus. Chimie
Subjects:
Praziquantel
Bitter taste
Sweeteners
Mechanochemistry
Taste-masking
Amorphous
Polymorphism
Online Access:https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.188/
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