QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta
Aim: to evaluate the incidence of QTc interval prolongation associated with the use of amiodarone, as well as factors that influence its occurrence. Methods: this was a descriptive retrospective study conducted from November 2010 until December 2011 using medical record of patients at ICCU Cipto Ma...
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Interna Publishing
2014-10-01
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| Series: | Acta Medica Indonesiana |
| Online Access: | https://mail.actamedindones.org/index.php/ijim/article/view/102 |
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| author | Nafrialdi Nafrialdi Theresia G Kurniawan Arini Setiawati Lukman H. Makmun |
| author_facet | Nafrialdi Nafrialdi Theresia G Kurniawan Arini Setiawati Lukman H. Makmun |
| author_sort | Nafrialdi Nafrialdi |
| collection | DOAJ |
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Aim: to evaluate the incidence of QTc interval prolongation associated with the use of amiodarone, as well as factors that influence its occurrence. Methods: this was a descriptive retrospective study conducted from November 2010 until December 2011 using medical record of patients at ICCU Cipto Mangunkusumo Hospital from 2004-2011. Four groups of patients were included: (1) patients receiving amiodarone and other drugs causing which can cause QTc prolongation, (2) patients receiving amiodarone and other drug not causing QTc prolongation, (3) patients receiving drugs which can cause causing QTc prolongation, (4) patients not receiving amiodarone, nor other drugs which can cause causing QTc prolongation (served as control group). Difference of QTc interval within the same group was analyzed with paired t-test or Wilcoxon matched-pairs test. Between groups comparison were performed with Kruskal Wallis test. The influence of other factors (sex, age, heart failure, liver disorder, electrolyte imbalance) on QTc prolongation was analyzed using multiple regression. Results: QTc interval prolongation in groups 1, 2, and 3 were respectively 65.5%, 63.3%, 56.6%, which were significantly different from control group (24.4%); Hypernatremia and hypertension were revealed as significant risk factor for QTc prolongation. Mortality occurred in 3, 4, and 4 patients in group 1, 2, and 3 respectively, and none in group 4. Conclusion: QTc interval prolongation occurred in association with amiodarone and other drugs known to prolong QTc interval. Hypernatremia and hypertension were shown as significant influencing factor of QTc interval prolongation.
Key words: amiodarone, antiarrhythmia, QTc interval
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| format | Article |
| id | doaj-art-18f71b5ca6b846b8ac5253d319a99912 |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-18f71b5ca6b846b8ac5253d319a999122025-08-20T03:13:44ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322014-10-01464QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, JakartaNafrialdi Nafrialdi0Theresia G Kurniawan1Arini Setiawati2Lukman H. Makmun3Department of Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaDepartment of Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaDepartment of Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia Aim: to evaluate the incidence of QTc interval prolongation associated with the use of amiodarone, as well as factors that influence its occurrence. Methods: this was a descriptive retrospective study conducted from November 2010 until December 2011 using medical record of patients at ICCU Cipto Mangunkusumo Hospital from 2004-2011. Four groups of patients were included: (1) patients receiving amiodarone and other drugs causing which can cause QTc prolongation, (2) patients receiving amiodarone and other drug not causing QTc prolongation, (3) patients receiving drugs which can cause causing QTc prolongation, (4) patients not receiving amiodarone, nor other drugs which can cause causing QTc prolongation (served as control group). Difference of QTc interval within the same group was analyzed with paired t-test or Wilcoxon matched-pairs test. Between groups comparison were performed with Kruskal Wallis test. The influence of other factors (sex, age, heart failure, liver disorder, electrolyte imbalance) on QTc prolongation was analyzed using multiple regression. Results: QTc interval prolongation in groups 1, 2, and 3 were respectively 65.5%, 63.3%, 56.6%, which were significantly different from control group (24.4%); Hypernatremia and hypertension were revealed as significant risk factor for QTc prolongation. Mortality occurred in 3, 4, and 4 patients in group 1, 2, and 3 respectively, and none in group 4. Conclusion: QTc interval prolongation occurred in association with amiodarone and other drugs known to prolong QTc interval. Hypernatremia and hypertension were shown as significant influencing factor of QTc interval prolongation. Key words: amiodarone, antiarrhythmia, QTc interval https://mail.actamedindones.org/index.php/ijim/article/view/102 |
| spellingShingle | Nafrialdi Nafrialdi Theresia G Kurniawan Arini Setiawati Lukman H. Makmun QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta Acta Medica Indonesiana |
| title | QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta |
| title_full | QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta |
| title_fullStr | QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta |
| title_full_unstemmed | QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta |
| title_short | QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta |
| title_sort | qt interval prolongation associated with amiodarone use in cipto mangunkusumo hospital jakarta |
| url | https://mail.actamedindones.org/index.php/ijim/article/view/102 |
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