Gut microbiota modulate immune responses to orally and parenterally administered rotavirus in mice

Gut microbiota modulate immune responses to orally and parenterally administered rotavirus in mice

Abstract Rotavirus (RV) remains a significant cause of infantile morbidity and mortality, while oral RV vaccines offer inconsistent protection. This study investigates whether gut microbiota influence immune responses to orally and intramuscularly (IM) administered RV strains. Using murine models, w...

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Bibliographic Details
Main Authors: Zhenda Shi, Sung-Sil Moon, Jun Zou, Yanling Wang, Noopur Bhatnagar, Vu L. Ngo, Xiaoqian Wang, Houping Wang, Theresa K. Bessey, Jennifer J. Hull, Yuhuan Wang, Sang-Moo Kang, Andrew T. Gewirtz, Baoming Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01126-9
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