Roles of Pho regulon in bacterial pathogenicity
Bacterial infections are a leading cause of global health loss. The prerequisites for bacteria to colonize and establish systemic infection in the host are environmental adaptability and the expression of virulence factors. Phosphorus constitutes the fifth most important element in terms of its cell...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2545559 |
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| author | Jing Yang Min Wang Yi Wang Rui Qiang Qiyuan Jin Chenhao Zhao Qi Chen Mingxiao Han Xin Ma Haifang Zhang |
| author_facet | Jing Yang Min Wang Yi Wang Rui Qiang Qiyuan Jin Chenhao Zhao Qi Chen Mingxiao Han Xin Ma Haifang Zhang |
| author_sort | Jing Yang |
| collection | DOAJ |
| description | Bacterial infections are a leading cause of global health loss. The prerequisites for bacteria to colonize and establish systemic infection in the host are environmental adaptability and the expression of virulence factors. Phosphorus constitutes the fifth most important element in terms of its cellular content, which is pivotal for DNA replication, metabolism, signal transmission, and microbial cell composition. The phosphate (Pho) regulon is a well-established unique mechanism in response to inorganic phosphate (Pi) starvation. The Pho regulon is strongly related to bacterial pathogenicity, except for the simple regulatory system for Pho balance. The PhoBR two-component regulatory system of the Pho regulon has documented the effects of affecting virulence in microbes. This review emphasizes the impact of the absence of PhoB and virulence-related gene regulation by PhoB on pathogenicity in common pathogens of Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica serovar Typhimurium, Vibrio cholerae, etc. Collectively, Pho regulon is a regulatory network connecting Pho homeostasis with bacterial virulence. This study may offer valuable information for understanding the regulation of bacterial virulence by the Pho regulon, providing novel insights for the development of antimicrobial strategies. |
| format | Article |
| id | doaj-art-18edf26b3e2c46cc8c539aa4af2d0d76 |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-18edf26b3e2c46cc8c539aa4af2d0d762025-08-20T04:00:50ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2545559Roles of Pho regulon in bacterial pathogenicityJing Yang0Min Wang1Yi Wang2Rui Qiang3Qiyuan Jin4Chenhao Zhao5Qi Chen6Mingxiao Han7Xin Ma8Haifang Zhang9Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaBacterial infections are a leading cause of global health loss. The prerequisites for bacteria to colonize and establish systemic infection in the host are environmental adaptability and the expression of virulence factors. Phosphorus constitutes the fifth most important element in terms of its cellular content, which is pivotal for DNA replication, metabolism, signal transmission, and microbial cell composition. The phosphate (Pho) regulon is a well-established unique mechanism in response to inorganic phosphate (Pi) starvation. The Pho regulon is strongly related to bacterial pathogenicity, except for the simple regulatory system for Pho balance. The PhoBR two-component regulatory system of the Pho regulon has documented the effects of affecting virulence in microbes. This review emphasizes the impact of the absence of PhoB and virulence-related gene regulation by PhoB on pathogenicity in common pathogens of Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica serovar Typhimurium, Vibrio cholerae, etc. Collectively, Pho regulon is a regulatory network connecting Pho homeostasis with bacterial virulence. This study may offer valuable information for understanding the regulation of bacterial virulence by the Pho regulon, providing novel insights for the development of antimicrobial strategies.https://www.tandfonline.com/doi/10.1080/21505594.2025.2545559Pho regulonphosphate homeostasisbacterial pathogenicity |
| spellingShingle | Jing Yang Min Wang Yi Wang Rui Qiang Qiyuan Jin Chenhao Zhao Qi Chen Mingxiao Han Xin Ma Haifang Zhang Roles of Pho regulon in bacterial pathogenicity Virulence Pho regulon phosphate homeostasis bacterial pathogenicity |
| title | Roles of Pho regulon in bacterial pathogenicity |
| title_full | Roles of Pho regulon in bacterial pathogenicity |
| title_fullStr | Roles of Pho regulon in bacterial pathogenicity |
| title_full_unstemmed | Roles of Pho regulon in bacterial pathogenicity |
| title_short | Roles of Pho regulon in bacterial pathogenicity |
| title_sort | roles of pho regulon in bacterial pathogenicity |
| topic | Pho regulon phosphate homeostasis bacterial pathogenicity |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2545559 |
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