Clinicopathologic characterization of secretory carcinoma of salivary gland
Abstract Background To investigate the clinicopathologic characteristics, therapeutic methods, and prognosis of secretory carcinoma of salivary gland (SCSG). Methods The clinicopathologic data of 13 patients with SCSG admitted to Shanxi Cancer Hospital from January 2018 to June 2023 were retrospecti...
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| Language: | English |
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BMC
2024-10-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-024-03561-9 |
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| author | Fei Han Feng Liu Hao Wang Yanchao Qin Qian Lu Xuesong Wu Zhen Guo Xinrong Nan |
| author_facet | Fei Han Feng Liu Hao Wang Yanchao Qin Qian Lu Xuesong Wu Zhen Guo Xinrong Nan |
| author_sort | Fei Han |
| collection | DOAJ |
| description | Abstract Background To investigate the clinicopathologic characteristics, therapeutic methods, and prognosis of secretory carcinoma of salivary gland (SCSG). Methods The clinicopathologic data of 13 patients with SCSG admitted to Shanxi Cancer Hospital from January 2018 to June 2023 were retrospectively analyzed, and a literature review was performed. Results A total of eight males and five females aged 22–78 years old were enrolled, and they commonly presented with painless masses in the parotid or submandibular gland. They all underwent surgical treatment, accompanied by typical pathological examinations postoperatively. Fluorescence in situ hybridization (FISH) was conducted in seven cases, the results were all positive, and no gene fusion other than ETV6-NTRK3 was found. Two patients developed local relapse during follow-up, both of which were in the surgical area. By the end of the follow-up, 12 patients survived and one patient died. Conclusions SCSG is a rare low-grade malignancy with a good prognosis. Pathological and immunohistochemical characteristics are the key to secretory carcinoma (SC) diagnosis, and surgical excision is the major treatment means for SCSG. Whether to perform simultaneous cervical lymph node dissection and other adjuvant therapies should be determined based on the pathological stage and the presence or absence of high-risk factors. |
| format | Article |
| id | doaj-art-18e503a714eb4de5b9ce219df0338547 |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-18e503a714eb4de5b9ce219df03385472025-08-20T04:02:54ZengBMCWorld Journal of Surgical Oncology1477-78192024-10-0122111110.1186/s12957-024-03561-9Clinicopathologic characterization of secretory carcinoma of salivary glandFei Han0Feng Liu1Hao Wang2Yanchao Qin3Qian Lu4Xuesong Wu5Zhen Guo6Xinrong Nan7Shanxi Medical University School and Hospital of StomatologyDepartment of Head and Neck Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Shanxi Provincial Cancer Hospital, Chinese Academy of Medical Sciences/Cancer HospitalAffiliated to Shanxi Medical UniversityShanxi Medical University School and Hospital of StomatologyDepartment of Head and Neck Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Shanxi Provincial Cancer Hospital, Chinese Academy of Medical Sciences/Cancer HospitalAffiliated to Shanxi Medical UniversitySecond Clinical Medical School, Shanxi Medical UniversityDepartment of Head and Neck Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Shanxi Provincial Cancer Hospital, Chinese Academy of Medical Sciences/Cancer HospitalAffiliated to Shanxi Medical UniversityDepartment of Head and Neck Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Shanxi Provincial Cancer Hospital, Chinese Academy of Medical Sciences/Cancer HospitalAffiliated to Shanxi Medical UniversityDepartment of Oral and Maxillofacial Surgery, First Hospital of Shanxi Medical UniversityAbstract Background To investigate the clinicopathologic characteristics, therapeutic methods, and prognosis of secretory carcinoma of salivary gland (SCSG). Methods The clinicopathologic data of 13 patients with SCSG admitted to Shanxi Cancer Hospital from January 2018 to June 2023 were retrospectively analyzed, and a literature review was performed. Results A total of eight males and five females aged 22–78 years old were enrolled, and they commonly presented with painless masses in the parotid or submandibular gland. They all underwent surgical treatment, accompanied by typical pathological examinations postoperatively. Fluorescence in situ hybridization (FISH) was conducted in seven cases, the results were all positive, and no gene fusion other than ETV6-NTRK3 was found. Two patients developed local relapse during follow-up, both of which were in the surgical area. By the end of the follow-up, 12 patients survived and one patient died. Conclusions SCSG is a rare low-grade malignancy with a good prognosis. Pathological and immunohistochemical characteristics are the key to secretory carcinoma (SC) diagnosis, and surgical excision is the major treatment means for SCSG. Whether to perform simultaneous cervical lymph node dissection and other adjuvant therapies should be determined based on the pathological stage and the presence or absence of high-risk factors.https://doi.org/10.1186/s12957-024-03561-9Secretory carcinomaSalivary gland tumorMammary analog secretory carcinoma |
| spellingShingle | Fei Han Feng Liu Hao Wang Yanchao Qin Qian Lu Xuesong Wu Zhen Guo Xinrong Nan Clinicopathologic characterization of secretory carcinoma of salivary gland World Journal of Surgical Oncology Secretory carcinoma Salivary gland tumor Mammary analog secretory carcinoma |
| title | Clinicopathologic characterization of secretory carcinoma of salivary gland |
| title_full | Clinicopathologic characterization of secretory carcinoma of salivary gland |
| title_fullStr | Clinicopathologic characterization of secretory carcinoma of salivary gland |
| title_full_unstemmed | Clinicopathologic characterization of secretory carcinoma of salivary gland |
| title_short | Clinicopathologic characterization of secretory carcinoma of salivary gland |
| title_sort | clinicopathologic characterization of secretory carcinoma of salivary gland |
| topic | Secretory carcinoma Salivary gland tumor Mammary analog secretory carcinoma |
| url | https://doi.org/10.1186/s12957-024-03561-9 |
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