Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis
To assess the relationship between aspartate aminotransferase-platelet ratio index (APRI) and liver fibrosis in children with chronic hepatocellular and biliary cholestatic liver diseases. A retrospective review of one hundred children's demographic and laboratory findings concurrent wit...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2015-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1273 |
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| author | Aysel Ünlüsoy Aksu Sinan Sarı Güldal Yılmaz Ödül Eğritaş Gürkan Zeliha Demirtaş Buket Dalgıç |
| author_facet | Aysel Ünlüsoy Aksu Sinan Sarı Güldal Yılmaz Ödül Eğritaş Gürkan Zeliha Demirtaş Buket Dalgıç |
| author_sort | Aysel Ünlüsoy Aksu |
| collection | DOAJ |
| description |
To assess the relationship between aspartate aminotransferase-platelet ratio index (APRI) and liver fibrosis in children with chronic hepatocellular and biliary cholestatic liver diseases. A retrospective review of one hundred children's demographic and laboratory findings concurrent with liver biopsy, who were followed-up with prolonged cholestasis. The diagnostic accuracy of the APRI was assessed by receiver operating characteristic (ROC) curves. Advanced fibrosis was more common in the hepatocellular group. The APRI values of the two groups were similar. The patients with advanced fibrosis had significantly higher APRI values than patients with mild fibrosis, in both the hepatocellular and biliary groups. The areas under the ROC were 0.68 and 0.81 in the hepatocellular and biliary groups respectively. The cut-off values of APRI for discriminating advanced fibrosis were 0.93 (65% sensitivity, 69% specificity) in the hepatocellular group and 2.35 (62% sensitivity, 96% specificity) in the biliary group. APRI may be most efficient for discriminating between advanced and mild fibrosis in biliary cholestatic liver disease patients.
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| format | Article |
| id | doaj-art-18e4f9d2652048b099a31f903ebfe707 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-18e4f9d2652048b099a31f903ebfe7072025-08-20T02:01:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212015-10-01575Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosisAysel Ünlüsoy Aksu0Sinan SarıGüldal YılmazÖdül Eğritaş GürkanZeliha DemirtaşBuket DalgıçDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey. To assess the relationship between aspartate aminotransferase-platelet ratio index (APRI) and liver fibrosis in children with chronic hepatocellular and biliary cholestatic liver diseases. A retrospective review of one hundred children's demographic and laboratory findings concurrent with liver biopsy, who were followed-up with prolonged cholestasis. The diagnostic accuracy of the APRI was assessed by receiver operating characteristic (ROC) curves. Advanced fibrosis was more common in the hepatocellular group. The APRI values of the two groups were similar. The patients with advanced fibrosis had significantly higher APRI values than patients with mild fibrosis, in both the hepatocellular and biliary groups. The areas under the ROC were 0.68 and 0.81 in the hepatocellular and biliary groups respectively. The cut-off values of APRI for discriminating advanced fibrosis were 0.93 (65% sensitivity, 69% specificity) in the hepatocellular group and 2.35 (62% sensitivity, 96% specificity) in the biliary group. APRI may be most efficient for discriminating between advanced and mild fibrosis in biliary cholestatic liver disease patients. https://turkjpediatr.org/article/view/1273 |
| spellingShingle | Aysel Ünlüsoy Aksu Sinan Sarı Güldal Yılmaz Ödül Eğritaş Gürkan Zeliha Demirtaş Buket Dalgıç Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis The Turkish Journal of Pediatrics |
| title | Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis |
| title_full | Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis |
| title_fullStr | Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis |
| title_full_unstemmed | Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis |
| title_short | Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis |
| title_sort | aspartate aminotransferase to platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis |
| url | https://turkjpediatr.org/article/view/1273 |
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