Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report
Introduction. Cytotoxic corpus callosum syndrome (CLOCC syndrome) is a rare neurological pathology, the pathogenesis of which has not been fully studied. The CLOCC syndrome, which develops in cancer patients, is a serious concomitant pathology that complicates anti-cancer treatment. Description of t...
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Russian Academy of Sciences, Tomsk National Research Medical Center
2025-05-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/3549 |
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| author | A. Yu. Terekhova A. B. Galitsyna A. M. Chelmakov N. A. Falaleeva V. A. Shuvaev A. A. Danilenko M. M. Geraskina T. A. Agababyan V. O. Ripp D. A. Manaenkov S. A. Ivanov |
| author_facet | A. Yu. Terekhova A. B. Galitsyna A. M. Chelmakov N. A. Falaleeva V. A. Shuvaev A. A. Danilenko M. M. Geraskina T. A. Agababyan V. O. Ripp D. A. Manaenkov S. A. Ivanov |
| author_sort | A. Yu. Terekhova |
| collection | DOAJ |
| description | Introduction. Cytotoxic corpus callosum syndrome (CLOCC syndrome) is a rare neurological pathology, the pathogenesis of which has not been fully studied. The CLOCC syndrome, which develops in cancer patients, is a serious concomitant pathology that complicates anti-cancer treatment. Description of the clinical case. A 34 year-old female patient was admitted to the A. F. Tsyba MRRC in August 2023 with a diagnosis of stage IV plasmoblastic lymphoma established at her place of residence. Taking into account the severity of the patient’s disease, EPOCH chemotherapy with intrathecal administration of cytostatics was immediately initiated to prevent neuroleukemia. Infectious complications (febrile neutropenia and enterocolitis) that developed during therapy caused neurological disorders, which together with MRI findings, were assessed as CLOCC syndrome. These changes regressed over several days during desmopressin treatment and massive dehydration therapy with crystalloid and glucose solutions. Histological re-examination of the first biopsy specimen and immunohistochemical studies revealed B-lymphoblastic lymphoma, which led to a correction of the further therapy plan. Conclusion. The cause of the development of CLOCC syndrome in this patient can be assumed to be a combination of the damaging effects of cytostatics on brain tissue and electrolyte imbalance. |
| format | Article |
| id | doaj-art-18e42bcd958f4accbcca33125d98c2d5 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2025-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-18e42bcd958f4accbcca33125d98c2d52025-08-20T03:56:41ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682025-05-0124216917610.21294/1814-4861-2025-24-2-169-1761346Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case reportA. Yu. Terekhova0A. B. Galitsyna1A. M. Chelmakov2N. A. Falaleeva3V. A. Shuvaev4A. A. Danilenko5M. M. Geraskina6T. A. Agababyan7V. O. Ripp8D. A. Manaenkov9S. A. Ivanov10A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia ; Obninsk Institute of Atomic Energy – branch of the National Research Nuclear University “MEPhI”Obninsk Institute of Atomic Energy – branch of the National Research Nuclear University “MEPhI”A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of RussiaA. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia ; Obninsk Institute of Atomic Energy – branch of the National Research Nuclear University “MEPhI”A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia ; Obninsk Institute of Atomic Energy – branch of the National Research Nuclear University “MEPhI”A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of RussiaObninsk Institute of Atomic Energy – branch of the National Research Nuclear University “MEPhI” ; Clinical Hospital No. 8 of the Federal Medical and Biological AgencyA. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia ; Obninsk Institute of Atomic Energy – branch of the National Research Nuclear University “MEPhI”A. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of RussiaA. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of RussiaA. Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia ; Obninsk Institute of Atomic Energy – branch of the National Research Nuclear University “MEPhI”Introduction. Cytotoxic corpus callosum syndrome (CLOCC syndrome) is a rare neurological pathology, the pathogenesis of which has not been fully studied. The CLOCC syndrome, which develops in cancer patients, is a serious concomitant pathology that complicates anti-cancer treatment. Description of the clinical case. A 34 year-old female patient was admitted to the A. F. Tsyba MRRC in August 2023 with a diagnosis of stage IV plasmoblastic lymphoma established at her place of residence. Taking into account the severity of the patient’s disease, EPOCH chemotherapy with intrathecal administration of cytostatics was immediately initiated to prevent neuroleukemia. Infectious complications (febrile neutropenia and enterocolitis) that developed during therapy caused neurological disorders, which together with MRI findings, were assessed as CLOCC syndrome. These changes regressed over several days during desmopressin treatment and massive dehydration therapy with crystalloid and glucose solutions. Histological re-examination of the first biopsy specimen and immunohistochemical studies revealed B-lymphoblastic lymphoma, which led to a correction of the further therapy plan. Conclusion. The cause of the development of CLOCC syndrome in this patient can be assumed to be a combination of the damaging effects of cytostatics on brain tissue and electrolyte imbalance.https://www.siboncoj.ru/jour/article/view/3549oncologyoncohematologyneurologylymphomanon-hodgkin’s lymphomaclocc syndrome |
| spellingShingle | A. Yu. Terekhova A. B. Galitsyna A. M. Chelmakov N. A. Falaleeva V. A. Shuvaev A. A. Danilenko M. M. Geraskina T. A. Agababyan V. O. Ripp D. A. Manaenkov S. A. Ivanov Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report Сибирский онкологический журнал oncology oncohematology neurology lymphoma non-hodgkin’s lymphoma clocc syndrome |
| title | Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report |
| title_full | Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report |
| title_fullStr | Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report |
| title_full_unstemmed | Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report |
| title_short | Features of CLOCC syndrome in the patient b-lymphoblastic lymphoma. A case report |
| title_sort | features of clocc syndrome in the patient b lymphoblastic lymphoma a case report |
| topic | oncology oncohematology neurology lymphoma non-hodgkin’s lymphoma clocc syndrome |
| url | https://www.siboncoj.ru/jour/article/view/3549 |
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