Research progress on ferroptosis in Myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are a group of malignancies characterized by clonal proliferation of hematopoietic stem cells, ineffective hematopoiesis, peripheral cytopenias, and a high risk of transformation to acute myeloid leukemia. Current therapeutic strategies for MDS have limited efficacy....
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1561072/full |
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| author | Yifan Yang Jiongping Han Yuxin Wei Jiacheng Jin Weiyin Feng |
| author_facet | Yifan Yang Jiongping Han Yuxin Wei Jiacheng Jin Weiyin Feng |
| author_sort | Yifan Yang |
| collection | DOAJ |
| description | Myelodysplastic syndromes (MDS) are a group of malignancies characterized by clonal proliferation of hematopoietic stem cells, ineffective hematopoiesis, peripheral cytopenias, and a high risk of transformation to acute myeloid leukemia. Current therapeutic strategies for MDS have limited efficacy. Thus, identifying new therapeutic targets and prognostic biomarkers is a critical future research direction. Ferroptosis, a new type of iron-dependent programmed cell death, has become a recent hotspot in the field of oncology research. Recent results have demonstrated that iron metabolism, lipid metabolism, and other pathways can be targeted to induce ferroptosis in MDS cells. In addition, ferroptosis-related genes are of significance in the prognosis and diagnosis of MDS. This article reviews the current research progress on ferroptosis in MDS, including its potential for targeting as a therapeutic intervention strategy. |
| format | Article |
| id | doaj-art-18e2ac126c56442f950fca6bbb7c6bfd |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-18e2ac126c56442f950fca6bbb7c6bfd2025-08-20T02:54:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15610721561072Research progress on ferroptosis in Myelodysplastic syndromesYifan Yang0Jiongping Han1Yuxin Wei2Jiacheng Jin3Weiyin Feng4School of Medicine, Shaoxing University, Shaoxing, Zhejing, ChinaSchool of Medicine, Shaoxing University, Shaoxing, Zhejing, ChinaSchool of Medicine, Shaoxing University, Shaoxing, Zhejing, ChinaDepartment of Hematology, Shaoxing People’s Hospital, Affiliated First Hospital of Shaoxing University, Shaoxing, ChinaDepartment of Hematology, Shaoxing People’s Hospital, Affiliated First Hospital of Shaoxing University, Shaoxing, ChinaMyelodysplastic syndromes (MDS) are a group of malignancies characterized by clonal proliferation of hematopoietic stem cells, ineffective hematopoiesis, peripheral cytopenias, and a high risk of transformation to acute myeloid leukemia. Current therapeutic strategies for MDS have limited efficacy. Thus, identifying new therapeutic targets and prognostic biomarkers is a critical future research direction. Ferroptosis, a new type of iron-dependent programmed cell death, has become a recent hotspot in the field of oncology research. Recent results have demonstrated that iron metabolism, lipid metabolism, and other pathways can be targeted to induce ferroptosis in MDS cells. In addition, ferroptosis-related genes are of significance in the prognosis and diagnosis of MDS. This article reviews the current research progress on ferroptosis in MDS, including its potential for targeting as a therapeutic intervention strategy.https://www.frontiersin.org/articles/10.3389/fphar.2025.1561072/fullMyelodysplastic syndromesferroptosissignal pathferroptosis-related genesferroptosis inducing drugs |
| spellingShingle | Yifan Yang Jiongping Han Yuxin Wei Jiacheng Jin Weiyin Feng Research progress on ferroptosis in Myelodysplastic syndromes Frontiers in Pharmacology Myelodysplastic syndromes ferroptosis signal path ferroptosis-related genes ferroptosis inducing drugs |
| title | Research progress on ferroptosis in Myelodysplastic syndromes |
| title_full | Research progress on ferroptosis in Myelodysplastic syndromes |
| title_fullStr | Research progress on ferroptosis in Myelodysplastic syndromes |
| title_full_unstemmed | Research progress on ferroptosis in Myelodysplastic syndromes |
| title_short | Research progress on ferroptosis in Myelodysplastic syndromes |
| title_sort | research progress on ferroptosis in myelodysplastic syndromes |
| topic | Myelodysplastic syndromes ferroptosis signal path ferroptosis-related genes ferroptosis inducing drugs |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1561072/full |
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