Elevated Siglec-7 expression correlates with adverse clinicopathological, immunological, and therapeutic response signatures in breast cancer patients

Elevated Siglec-7 expression correlates with adverse clinicopathological, immunological, and therapeutic response signatures in breast cancer patients

IntroductionBreast cancer is a highly heterogeneous malignancy, characterized by an intricate, hypersialylated tumor microenvironment that actively inhibits immune functions. Although immune checkpoint inhibitors have marked clinical advantages in various tumor types, their efficacy in Triple-Negati...

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Bibliographic Details
Main Authors: Hamza Benthami, Basma Zohair, Ibtissam Rezouki, Oumayma Naji, Kenza Miyara, Simohamed Ennachit, Mohamed Elkarroumi, Hind Aschawa, Abdallah Badou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Siglec-7
A2AR
tumor microenvironment
immunosuppression
immune checkpoint
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1573365/full
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