Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis
Abstract Background This study investigated the association between prostaglandins, vitamin D levels, and their potential role in acute myeloid leukemia (AML). Previous research has shown prostaglandins’ stimulatory effects and vitamin D’s inhibitory effects in various malignancies. Methods This cro...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-83736-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849390308093067264 |
|---|---|
| author | Hossein Ghasemi Moghaddam Nasrin Gholami Ali Esfahani Zohreh Ghoreishi Amirreza Khalaji |
| author_facet | Hossein Ghasemi Moghaddam Nasrin Gholami Ali Esfahani Zohreh Ghoreishi Amirreza Khalaji |
| author_sort | Hossein Ghasemi Moghaddam |
| collection | DOAJ |
| description | Abstract Background This study investigated the association between prostaglandins, vitamin D levels, and their potential role in acute myeloid leukemia (AML). Previous research has shown prostaglandins’ stimulatory effects and vitamin D’s inhibitory effects in various malignancies. Methods This cross-sectional study evaluated 54 AML patients at Shahid Ghazi Center of Imam Reza Hospital in Tabriz. Prostaglandin E2 (PGE2), Cyclooxygenase-2 (COX-2), and serum vitamin D levels, as well as gene expression of 5-hydroxyprostaglandin dehydrogenase (15-PGDH), COX-2, PGE2 synthase, and vitamin D receptor (VDR), were measured. Relationships were assessed between vitamin D levels, COX-2 and PGE2 expression, serum levels, and treatment outcomes. Results Median serum vitamin D level was 18.25 ng/mL (range: 4.00-72.70). There was no significant association between serum vitamin D levels and expression or serum levels of COX-2, PGE2 synthase, and 15-PGDH. VDR gene expression and serum levels showed significant direct correlations with PGE2 and COX-2 gene expression and serum concentrations and inverse correlations with 15-PGDH expression (P < 0.05). No statistically significant correlation was observed between vitamin D status, PGE2, COX-2, and 15-PGDH with treatment outcomes. Conclusion This study on AML patients showed no significant correlation between vitamin D levels and COX-2, PGE2 synthase, or 15-PGDH. VDR expression correlated positively with PGE2 and COX-2 but negatively with 15-PGDH. No associations were found between these factors and therapy outcomes. |
| format | Article |
| id | doaj-art-18e0974b907f4d609780a04d0b330df3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-18e0974b907f4d609780a04d0b330df32025-08-20T03:41:42ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-83736-2Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysisHossein Ghasemi Moghaddam0Nasrin Gholami1Ali Esfahani2Zohreh Ghoreishi3Amirreza Khalaji4Hematology and Oncology Research Center, Tabriz University of Medical SciencesHematology and Oncology Research Center, Tabriz University of Medical SciencesHematology and Oncology Research Center, Tabriz University of Medical SciencesDepartment of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical SciencesImmunology Research Center, Tabriz University of Medical SciencesAbstract Background This study investigated the association between prostaglandins, vitamin D levels, and their potential role in acute myeloid leukemia (AML). Previous research has shown prostaglandins’ stimulatory effects and vitamin D’s inhibitory effects in various malignancies. Methods This cross-sectional study evaluated 54 AML patients at Shahid Ghazi Center of Imam Reza Hospital in Tabriz. Prostaglandin E2 (PGE2), Cyclooxygenase-2 (COX-2), and serum vitamin D levels, as well as gene expression of 5-hydroxyprostaglandin dehydrogenase (15-PGDH), COX-2, PGE2 synthase, and vitamin D receptor (VDR), were measured. Relationships were assessed between vitamin D levels, COX-2 and PGE2 expression, serum levels, and treatment outcomes. Results Median serum vitamin D level was 18.25 ng/mL (range: 4.00-72.70). There was no significant association between serum vitamin D levels and expression or serum levels of COX-2, PGE2 synthase, and 15-PGDH. VDR gene expression and serum levels showed significant direct correlations with PGE2 and COX-2 gene expression and serum concentrations and inverse correlations with 15-PGDH expression (P < 0.05). No statistically significant correlation was observed between vitamin D status, PGE2, COX-2, and 15-PGDH with treatment outcomes. Conclusion This study on AML patients showed no significant correlation between vitamin D levels and COX-2, PGE2 synthase, or 15-PGDH. VDR expression correlated positively with PGE2 and COX-2 but negatively with 15-PGDH. No associations were found between these factors and therapy outcomes.https://doi.org/10.1038/s41598-024-83736-2Vitamin D15-PGDHProstaglandinsVitamin D receptor (VDR) |
| spellingShingle | Hossein Ghasemi Moghaddam Nasrin Gholami Ali Esfahani Zohreh Ghoreishi Amirreza Khalaji Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis Scientific Reports Vitamin D 15-PGDH Prostaglandins Vitamin D receptor (VDR) |
| title | Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis |
| title_full | Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis |
| title_fullStr | Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis |
| title_full_unstemmed | Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis |
| title_short | Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis |
| title_sort | serum vitamin d levels and their correlation with pro inflammatory prostaglandins in acute myeloid leukemia a cross sectional analysis |
| topic | Vitamin D 15-PGDH Prostaglandins Vitamin D receptor (VDR) |
| url | https://doi.org/10.1038/s41598-024-83736-2 |
| work_keys_str_mv | AT hosseinghasemimoghaddam serumvitamindlevelsandtheircorrelationwithproinflammatoryprostaglandinsinacutemyeloidleukemiaacrosssectionalanalysis AT nasringholami serumvitamindlevelsandtheircorrelationwithproinflammatoryprostaglandinsinacutemyeloidleukemiaacrosssectionalanalysis AT aliesfahani serumvitamindlevelsandtheircorrelationwithproinflammatoryprostaglandinsinacutemyeloidleukemiaacrosssectionalanalysis AT zohrehghoreishi serumvitamindlevelsandtheircorrelationwithproinflammatoryprostaglandinsinacutemyeloidleukemiaacrosssectionalanalysis AT amirrezakhalaji serumvitamindlevelsandtheircorrelationwithproinflammatoryprostaglandinsinacutemyeloidleukemiaacrosssectionalanalysis |