A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions
Background. Cutaneous leishmaniasis is an endemic disease in Iran. Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years. However, the cure rate of these agents is still not favorable. This study was carried out to compare the efficacies of intral...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6462804 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567148070830080 |
|---|---|
| author | Fariba Jaffary Mohammad Ali Nilforoushzadeh Amirhossein Siadat Elaheh Haftbaradaran Nazli Ansari Elham Ahmadi |
| author_facet | Fariba Jaffary Mohammad Ali Nilforoushzadeh Amirhossein Siadat Elaheh Haftbaradaran Nazli Ansari Elham Ahmadi |
| author_sort | Fariba Jaffary |
| collection | DOAJ |
| description | Background. Cutaneous leishmaniasis is an endemic disease in Iran. Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years. However, the cure rate of these agents is still not favorable. This study was carried out to compare the efficacies of intralesional glucantime with topical trichloroacetic acid 50% (TCA 50%) + glucantime and fractional carbon dioxide laser + glucantime in the treatment of cutaneous leishmaniasis. Methods. A total of 90 patients were randomly divided into three groups of 30 to be treated with intralesional injection of glucantime, a combination of topical TCA 50% and glucantime, or a combination of fractional laser and glucantime. The overall clinical improvement and changes in sizes of lesions and scars were assessed and compared among three groups. Results. The mean duration of treatment was 6.1±2.1 weeks in all patients (range: 2–12 weeks) and 6.8±1.7, 5.2±1.0, and 6.3±3.0 weeks in glucantime, topical TCA plus glucantime, and fractional laser plus glucantime groups, respectively (P=0.011). Complete improvement was observed in 10 (38.5%), 27 (90%), and 20 (87%) patients of glucantime, glucantime + TCA, and glucantime + laser groups, respectively (P<0.001). Conclusion. Compared to glucantime alone, the combination of intralesional glucantime and TCA 50% or fractional CO2 laser had significantly higher and faster cure rate in patients with cutaneous leishmaniasis. |
| format | Article |
| id | doaj-art-18df0ad4fd144e3ba5ae72fab7058c89 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-18df0ad4fd144e3ba5ae72fab7058c892025-02-03T01:02:06ZengWileyDermatology Research and Practice1687-61051687-61132016-01-01201610.1155/2016/64628046462804A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis LesionsFariba Jaffary0Mohammad Ali Nilforoushzadeh1Amirhossein Siadat2Elaheh Haftbaradaran3Nazli Ansari4Elham Ahmadi5Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan 8187698191, IranSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran 1937957514, IranDepartment of Dermatology, Isfahan University of Medical Sciences, Isfahan 8174675731, IranSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan 8187698191, IranSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan 8187698191, IranSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan 8187698191, IranBackground. Cutaneous leishmaniasis is an endemic disease in Iran. Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years. However, the cure rate of these agents is still not favorable. This study was carried out to compare the efficacies of intralesional glucantime with topical trichloroacetic acid 50% (TCA 50%) + glucantime and fractional carbon dioxide laser + glucantime in the treatment of cutaneous leishmaniasis. Methods. A total of 90 patients were randomly divided into three groups of 30 to be treated with intralesional injection of glucantime, a combination of topical TCA 50% and glucantime, or a combination of fractional laser and glucantime. The overall clinical improvement and changes in sizes of lesions and scars were assessed and compared among three groups. Results. The mean duration of treatment was 6.1±2.1 weeks in all patients (range: 2–12 weeks) and 6.8±1.7, 5.2±1.0, and 6.3±3.0 weeks in glucantime, topical TCA plus glucantime, and fractional laser plus glucantime groups, respectively (P=0.011). Complete improvement was observed in 10 (38.5%), 27 (90%), and 20 (87%) patients of glucantime, glucantime + TCA, and glucantime + laser groups, respectively (P<0.001). Conclusion. Compared to glucantime alone, the combination of intralesional glucantime and TCA 50% or fractional CO2 laser had significantly higher and faster cure rate in patients with cutaneous leishmaniasis.http://dx.doi.org/10.1155/2016/6462804 |
| spellingShingle | Fariba Jaffary Mohammad Ali Nilforoushzadeh Amirhossein Siadat Elaheh Haftbaradaran Nazli Ansari Elham Ahmadi A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions Dermatology Research and Practice |
| title | A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions |
| title_full | A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions |
| title_fullStr | A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions |
| title_full_unstemmed | A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions |
| title_short | A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions |
| title_sort | comparison between the effects of glucantime topical trichloroacetic acid 50 plus glucantime and fractional carbon dioxide laser plus glucantime on cutaneous leishmaniasis lesions |
| url | http://dx.doi.org/10.1155/2016/6462804 |
| work_keys_str_mv | AT faribajaffary acomparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT mohammadalinilforoushzadeh acomparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT amirhosseinsiadat acomparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT elahehhaftbaradaran acomparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT nazliansari acomparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT elhamahmadi acomparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT faribajaffary comparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT mohammadalinilforoushzadeh comparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT amirhosseinsiadat comparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT elahehhaftbaradaran comparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT nazliansari comparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions AT elhamahmadi comparisonbetweentheeffectsofglucantimetopicaltrichloroaceticacid50plusglucantimeandfractionalcarbondioxidelaserplusglucantimeoncutaneousleishmaniasislesions |