Design and performance verification of a novel vascular anastomosis connector
Abstract Rapid and safe vascular anastomosis can improve the success rate of surgical procedures and further promote wound healing in patients. Vascular anastomosis connectors (VACs) hold significant potential for facilitating rapid and safe anastomosis. In this study, polylactic acid (PLA) and poly...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-06163-x |
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| author | Fuqiang Lai Changsheng Cao Weiqiang Zou Yumei Li Wenge Liu Zhihuang Qiu Liangwan Chen |
| author_facet | Fuqiang Lai Changsheng Cao Weiqiang Zou Yumei Li Wenge Liu Zhihuang Qiu Liangwan Chen |
| author_sort | Fuqiang Lai |
| collection | DOAJ |
| description | Abstract Rapid and safe vascular anastomosis can improve the success rate of surgical procedures and further promote wound healing in patients. Vascular anastomosis connectors (VACs) hold significant potential for facilitating rapid and safe anastomosis. In this study, polylactic acid (PLA) and polycarbonate (PC-ISO) are selected as the materials to prepare VACs. The biomedical properties of the two materials are evaluated, and based on these results, conical thread snap-type VACs are designed. The anastomotic performance of the VACs is assessed using an extracorporeal mock circulation system (MCS). The results show that both PLA and PC-ISO degrade slowly in a simulated body fluid environment, with the sample weight change remaining within 0.37 wt%. Moreover, both materials exhibit good blood compatibility, showing no potential cytotoxicity. In addition, cells adhere well to their surfaces for proliferation, indicating strong biocompatibility. The in vitro MCS simulation tests reveal that both types of VACs can achieve rapid vascular anastomosis, meeting the performance requirements for tensile strength and leak resistance. |
| format | Article |
| id | doaj-art-18db58ebe7fd4a03b69c96d9a84f7a90 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-18db58ebe7fd4a03b69c96d9a84f7a902025-08-20T03:45:35ZengNature PortfolioScientific Reports2045-23222025-07-0115111410.1038/s41598-025-06163-xDesign and performance verification of a novel vascular anastomosis connectorFuqiang Lai0Changsheng Cao1Weiqiang Zou2Yumei Li3Wenge Liu4Zhihuang Qiu5Liangwan Chen6Department of Cardiovascular Surgery, Fujian Medical University Union HospitalSchool of Mechanical Engineering and Automation, Fuzhou UniversitySchool of Mechanical Engineering and Automation, Fuzhou UniversityDepartment of Cardiovascular Surgery, Fujian Medical University Union HospitalDepartment of Orthopedics, Fujian Medical University Union HospitalDepartment of Cardiovascular Surgery, Fujian Medical University Union HospitalDepartment of Cardiovascular Surgery, Fujian Medical University Union HospitalAbstract Rapid and safe vascular anastomosis can improve the success rate of surgical procedures and further promote wound healing in patients. Vascular anastomosis connectors (VACs) hold significant potential for facilitating rapid and safe anastomosis. In this study, polylactic acid (PLA) and polycarbonate (PC-ISO) are selected as the materials to prepare VACs. The biomedical properties of the two materials are evaluated, and based on these results, conical thread snap-type VACs are designed. The anastomotic performance of the VACs is assessed using an extracorporeal mock circulation system (MCS). The results show that both PLA and PC-ISO degrade slowly in a simulated body fluid environment, with the sample weight change remaining within 0.37 wt%. Moreover, both materials exhibit good blood compatibility, showing no potential cytotoxicity. In addition, cells adhere well to their surfaces for proliferation, indicating strong biocompatibility. The in vitro MCS simulation tests reveal that both types of VACs can achieve rapid vascular anastomosis, meeting the performance requirements for tensile strength and leak resistance.https://doi.org/10.1038/s41598-025-06163-xVascular anastomosis connectorMedical performance evaluationMock circulation systemAnastomotic performance |
| spellingShingle | Fuqiang Lai Changsheng Cao Weiqiang Zou Yumei Li Wenge Liu Zhihuang Qiu Liangwan Chen Design and performance verification of a novel vascular anastomosis connector Scientific Reports Vascular anastomosis connector Medical performance evaluation Mock circulation system Anastomotic performance |
| title | Design and performance verification of a novel vascular anastomosis connector |
| title_full | Design and performance verification of a novel vascular anastomosis connector |
| title_fullStr | Design and performance verification of a novel vascular anastomosis connector |
| title_full_unstemmed | Design and performance verification of a novel vascular anastomosis connector |
| title_short | Design and performance verification of a novel vascular anastomosis connector |
| title_sort | design and performance verification of a novel vascular anastomosis connector |
| topic | Vascular anastomosis connector Medical performance evaluation Mock circulation system Anastomotic performance |
| url | https://doi.org/10.1038/s41598-025-06163-x |
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