Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients
Diabetes mellitus has been regarded as a condition capable of influencing the evolution of periapical lesions. Therefore, this study evaluated the immunoexpression of IL-1β, TNF-α, and IL-17 in apical periodontitis from type 2 diabetic patients through immunohistochemistry. Twenty-six periapical les...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2023/4961827 |
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| author | Estéfano Borgo Sarmento Rosana Helena Teixeira de Lima Ribeiro Andrade Cinthya Cristina Gomes Fábio Ramôa Pires Maria Isabel Bastos Valente Adalgiza Mafra Moreno Marco Orsini Dennis Carvalho Ferreira Lucio Souza Gonçalves Luciana Armada |
| author_facet | Estéfano Borgo Sarmento Rosana Helena Teixeira de Lima Ribeiro Andrade Cinthya Cristina Gomes Fábio Ramôa Pires Maria Isabel Bastos Valente Adalgiza Mafra Moreno Marco Orsini Dennis Carvalho Ferreira Lucio Souza Gonçalves Luciana Armada |
| author_sort | Estéfano Borgo Sarmento |
| collection | DOAJ |
| description | Diabetes mellitus has been regarded as a condition capable of influencing the evolution of periapical lesions. Therefore, this study evaluated the immunoexpression of IL-1β, TNF-α, and IL-17 in apical periodontitis from type 2 diabetic patients through immunohistochemistry. Twenty-six periapical lesions were selected, and the images obtained through immunohistochemistry reactions were analyzed. The statistical significance was set at p<0.05. IL-1β expression was considered focal (54%), weak to moderate (38%), and strong (8%) in diabetics, and focal (46%), weak to moderate (31%), and strong (23%), in controls. TNF-α was focal (85%) and weak to moderate (15%) in diabetics, and focal (92%) and weak to moderate (8%), in controls. IL-17 was focal (8%), weak to moderate (46%), and strong (46%) in diabetics, and focal (62%), weak to moderate (8%), and strong (30%), in controls. The quantitative analysis revealed greater expression of IL-17, with a significant difference between IL-17 × IL-1β × TNF-αp=0.0009 in the diabetic group. The cytokines IL-1β and TNF-α did not express statistical differences between the tested groups. The IL-17 showed higher immunoexpression in the diabetic group p=0.047, which may suggest higher bone resorption activity in chronic apical periodontitis in this group of patients. |
| format | Article |
| id | doaj-art-18d9d2acce4f4c41988d041faf1be07e |
| institution | Kabale University |
| issn | 1687-8736 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-18d9d2acce4f4c41988d041faf1be07e2025-02-03T06:04:52ZengWileyInternational Journal of Dentistry1687-87362023-01-01202310.1155/2023/4961827Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic PatientsEstéfano Borgo Sarmento0Rosana Helena Teixeira de Lima Ribeiro Andrade1Cinthya Cristina Gomes2Fábio Ramôa Pires3Maria Isabel Bastos Valente4Adalgiza Mafra Moreno5Marco Orsini6Dennis Carvalho Ferreira7Lucio Souza Gonçalves8Luciana Armada9Postgraduate ProgramPostgraduate Program in DentistryPostgraduate ProgramPostgraduate Program in DentistryPostgraduate ProgramIguaçu UniversityIguaçu UniversityPostgraduate Program in DentistryPostgraduate Program in DentistryPostgraduate Program in DentistryDiabetes mellitus has been regarded as a condition capable of influencing the evolution of periapical lesions. Therefore, this study evaluated the immunoexpression of IL-1β, TNF-α, and IL-17 in apical periodontitis from type 2 diabetic patients through immunohistochemistry. Twenty-six periapical lesions were selected, and the images obtained through immunohistochemistry reactions were analyzed. The statistical significance was set at p<0.05. IL-1β expression was considered focal (54%), weak to moderate (38%), and strong (8%) in diabetics, and focal (46%), weak to moderate (31%), and strong (23%), in controls. TNF-α was focal (85%) and weak to moderate (15%) in diabetics, and focal (92%) and weak to moderate (8%), in controls. IL-17 was focal (8%), weak to moderate (46%), and strong (46%) in diabetics, and focal (62%), weak to moderate (8%), and strong (30%), in controls. The quantitative analysis revealed greater expression of IL-17, with a significant difference between IL-17 × IL-1β × TNF-αp=0.0009 in the diabetic group. The cytokines IL-1β and TNF-α did not express statistical differences between the tested groups. The IL-17 showed higher immunoexpression in the diabetic group p=0.047, which may suggest higher bone resorption activity in chronic apical periodontitis in this group of patients.http://dx.doi.org/10.1155/2023/4961827 |
| spellingShingle | Estéfano Borgo Sarmento Rosana Helena Teixeira de Lima Ribeiro Andrade Cinthya Cristina Gomes Fábio Ramôa Pires Maria Isabel Bastos Valente Adalgiza Mafra Moreno Marco Orsini Dennis Carvalho Ferreira Lucio Souza Gonçalves Luciana Armada Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients International Journal of Dentistry |
| title | Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients |
| title_full | Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients |
| title_fullStr | Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients |
| title_full_unstemmed | Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients |
| title_short | Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients |
| title_sort | proinflammatory cytokine expression in apical periodontitis from diabetic patients |
| url | http://dx.doi.org/10.1155/2023/4961827 |
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