Improving ALS detection and cognitive impairment stratification with attention-enhanced deep learning models

Improving ALS detection and cognitive impairment stratification with attention-enhanced deep learning models

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease marked by motor deterioration and cognitive decline. Early diagnosis is challenging due to the complexity of sporadic ALS and the lack of a defined risk population. In this study, we developed Miniset-DenseSENet, a convolut...

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Bibliographic Details
Main Authors: Yuqing Xia, Jenna M. Gregory, Fergal M. Waldron, Holly Spence, Marta Vallejo
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Amyotrophic lateral sclerosis
TDP-43 protein
Cognitive impairment
Transfer learning
Attention mechanisms
Online Access:https://doi.org/10.1038/s41598-025-90881-9
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