Primary Cardiac Lymphoma: Importance of Tissue Diagnosis
Primary cardiac lymphoma (PCL) is a rare disease entity that can present with severe cardiac and cardioembolic symptoms. We present a 79-year-old male with history of polymalgia rheumatica on chronic prednisone who presented with a two-week history of progressively worsening dyspnea, cough, and a 10...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/6192452 |
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| _version_ | 1832545350816104448 |
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| author | Lauren Mendelson Emily Hsu Hojune Chung Andrew Hsu |
| author_facet | Lauren Mendelson Emily Hsu Hojune Chung Andrew Hsu |
| author_sort | Lauren Mendelson |
| collection | DOAJ |
| description | Primary cardiac lymphoma (PCL) is a rare disease entity that can present with severe cardiac and cardioembolic symptoms. We present a 79-year-old male with history of polymalgia rheumatica on chronic prednisone who presented with a two-week history of progressively worsening dyspnea, cough, and a 10 pound weight loss. Transthoracic echocardiogram (TTE) and computed tomography (CT) of the chest showed a large mediastinal mass with invasion of the pericardium. A biopsy of an abdominal soft-tissue mass confirmed the diagnosis of PCL. The patient was treated with two cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) which was complicated by progressive heart failure requiring substitution of liposomal doxorubicin. The epidemiology, presentation, diagnosis, and treatment options of PCL are discussed. |
| format | Article |
| id | doaj-art-18d143077be34d1db3d1ce110f7cf5d7 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-18d143077be34d1db3d1ce110f7cf5d72025-02-03T07:26:06ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/61924526192452Primary Cardiac Lymphoma: Importance of Tissue DiagnosisLauren Mendelson0Emily Hsu1Hojune Chung2Andrew Hsu3Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USADepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USADepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USADepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USAPrimary cardiac lymphoma (PCL) is a rare disease entity that can present with severe cardiac and cardioembolic symptoms. We present a 79-year-old male with history of polymalgia rheumatica on chronic prednisone who presented with a two-week history of progressively worsening dyspnea, cough, and a 10 pound weight loss. Transthoracic echocardiogram (TTE) and computed tomography (CT) of the chest showed a large mediastinal mass with invasion of the pericardium. A biopsy of an abdominal soft-tissue mass confirmed the diagnosis of PCL. The patient was treated with two cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) which was complicated by progressive heart failure requiring substitution of liposomal doxorubicin. The epidemiology, presentation, diagnosis, and treatment options of PCL are discussed.http://dx.doi.org/10.1155/2018/6192452 |
| spellingShingle | Lauren Mendelson Emily Hsu Hojune Chung Andrew Hsu Primary Cardiac Lymphoma: Importance of Tissue Diagnosis Case Reports in Hematology |
| title | Primary Cardiac Lymphoma: Importance of Tissue Diagnosis |
| title_full | Primary Cardiac Lymphoma: Importance of Tissue Diagnosis |
| title_fullStr | Primary Cardiac Lymphoma: Importance of Tissue Diagnosis |
| title_full_unstemmed | Primary Cardiac Lymphoma: Importance of Tissue Diagnosis |
| title_short | Primary Cardiac Lymphoma: Importance of Tissue Diagnosis |
| title_sort | primary cardiac lymphoma importance of tissue diagnosis |
| url | http://dx.doi.org/10.1155/2018/6192452 |
| work_keys_str_mv | AT laurenmendelson primarycardiaclymphomaimportanceoftissuediagnosis AT emilyhsu primarycardiaclymphomaimportanceoftissuediagnosis AT hojunechung primarycardiaclymphomaimportanceoftissuediagnosis AT andrewhsu primarycardiaclymphomaimportanceoftissuediagnosis |