Disseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literature
Abstract Background Idiopathic CD4+ T lymphocytopenia is a rare immune dysfunction disease that is usually found after opportunistic infections. Mycobacterium abscessus is a rapidly growing mycobacterium that can cause pulmonary infections, lymphadenitis, skin and soft tissue infections, disseminate...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-024-05009-w |
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| author | Xianglin Wu Mingzhu Zhai Aohong Xu Yi Zheng |
| author_facet | Xianglin Wu Mingzhu Zhai Aohong Xu Yi Zheng |
| author_sort | Xianglin Wu |
| collection | DOAJ |
| description | Abstract Background Idiopathic CD4+ T lymphocytopenia is a rare immune dysfunction disease that is usually found after opportunistic infections. Mycobacterium abscessus is a rapidly growing mycobacterium that can cause pulmonary infections, lymphadenitis, skin and soft tissue infections, disseminated infections, among others, as a conditional pathogenic bacterium. Case presentation We present the case of a 43-year-old Chinese woman who developed disseminated Mycobacterium abscessus infection due to idiopathic CD4+ T lymphocytopenia. The patient exhibited symptoms including skin infections, lymphadenitis, and bacteremia. A tailored multidrug therapy was initiated, guided by drug susceptibility testing. Within a month of treatment, the patient’s fever resolved, and she exhibited a significant recovery and was discharged. Conclusions Cases of clinical idiopathic CD4+ T lymphocytopenia with Mycobacterium abscessus infection are not common. Clinicians should be vigilant and accurately identify Mycobacterium abscessus as an opportunistic pathogen when dealing with immunocompromised patients, in particular with idiopathic CD4+ T lymphocytopenia. |
| format | Article |
| id | doaj-art-18cd010edcaa49178aecb11cf0ee591e |
| institution | Kabale University |
| issn | 1752-1947 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-18cd010edcaa49178aecb11cf0ee591e2025-01-05T12:31:08ZengBMCJournal of Medical Case Reports1752-19472024-12-011811610.1186/s13256-024-05009-wDisseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literatureXianglin Wu0Mingzhu Zhai1Aohong Xu2Yi Zheng3Department of Laboratory Medicine, Guangming District People’s HospitalCenter for Medical Experiments (CME), Guangming District People’s HospitalCenter for Medical Experiments (CME), Guangming District People’s HospitalCenter for Medical Experiments (CME), Guangming District People’s HospitalAbstract Background Idiopathic CD4+ T lymphocytopenia is a rare immune dysfunction disease that is usually found after opportunistic infections. Mycobacterium abscessus is a rapidly growing mycobacterium that can cause pulmonary infections, lymphadenitis, skin and soft tissue infections, disseminated infections, among others, as a conditional pathogenic bacterium. Case presentation We present the case of a 43-year-old Chinese woman who developed disseminated Mycobacterium abscessus infection due to idiopathic CD4+ T lymphocytopenia. The patient exhibited symptoms including skin infections, lymphadenitis, and bacteremia. A tailored multidrug therapy was initiated, guided by drug susceptibility testing. Within a month of treatment, the patient’s fever resolved, and she exhibited a significant recovery and was discharged. Conclusions Cases of clinical idiopathic CD4+ T lymphocytopenia with Mycobacterium abscessus infection are not common. Clinicians should be vigilant and accurately identify Mycobacterium abscessus as an opportunistic pathogen when dealing with immunocompromised patients, in particular with idiopathic CD4+ T lymphocytopenia.https://doi.org/10.1186/s13256-024-05009-wBloodstream infectionMycobacterium abscessusClinical characteristicsAntimicrobial susceptibility testIdiopathic CD4+ T-lymphocytopenia (ICL) |
| spellingShingle | Xianglin Wu Mingzhu Zhai Aohong Xu Yi Zheng Disseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literature Journal of Medical Case Reports Bloodstream infection Mycobacterium abscessus Clinical characteristics Antimicrobial susceptibility test Idiopathic CD4+ T-lymphocytopenia (ICL) |
| title | Disseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literature |
| title_full | Disseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literature |
| title_fullStr | Disseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literature |
| title_full_unstemmed | Disseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literature |
| title_short | Disseminated Mycobacterium abscessus infection with idiopathic CD4+ T-lymphocytopenia: a case report and review of the literature |
| title_sort | disseminated mycobacterium abscessus infection with idiopathic cd4 t lymphocytopenia a case report and review of the literature |
| topic | Bloodstream infection Mycobacterium abscessus Clinical characteristics Antimicrobial susceptibility test Idiopathic CD4+ T-lymphocytopenia (ICL) |
| url | https://doi.org/10.1186/s13256-024-05009-w |
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