Amiodarone Pulmonary Toxicity
Amiodarone is an antiarrhythmic agent commonly used to treat supraventricular and ventricular arrhythmias. This drug is an iodine-containing compound that tends to accumulate in several organs, including the lungs. It has been associated with a variety of adverse events. Of these events, the most se...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2009/282540 |
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| author | Norman Wolkove Marc Baltzan |
| author_facet | Norman Wolkove Marc Baltzan |
| author_sort | Norman Wolkove |
| collection | DOAJ |
| description | Amiodarone is an antiarrhythmic agent commonly used to treat supraventricular and ventricular arrhythmias. This drug is an iodine-containing compound that tends to accumulate in several organs, including the lungs. It has been associated with a variety of adverse events. Of these events, the most serious is amiodarone pulmonary toxicity. Although the incidence of this complication has decreased with the use of lower doses of amiodarone, it can occur with any dose. Because amiodarone is widely used, all clinicians should be vigilant of this possibility. Pulmonary toxicity usually manifests as an acute or subacute pneumonitis, typically with diffuse infiltrates on chest x-ray and high-resolution computed tomography. Other, more localized, forms of pulmonary toxicity may occur, including pleural disease, migratory infiltrates, and single or multiple nodules. With early detection, the prognosis is good. Most patients diagnosed promptly respond well to the withdrawal of amiodarone and the administration of corticosteroids, which are usually given for four to 12 months. It is important that physicians be familiar with amiodarone treatment guidelines and follow published recommendations for the monitoring of pulmonary as well as extrapulmonary adverse effects. |
| format | Article |
| id | doaj-art-18be22b204b84928ab390443c2a442ac |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-18be22b204b84928ab390443c2a442ac2025-02-03T01:28:25ZengWileyCanadian Respiratory Journal1198-22412009-01-01162434810.1155/2009/282540Amiodarone Pulmonary ToxicityNorman Wolkove0Marc Baltzan1Mount Sinai Hospital Center, McGill University, Montreal, Quebec, CanadaMount Sinai Hospital Center, McGill University, Montreal, Quebec, CanadaAmiodarone is an antiarrhythmic agent commonly used to treat supraventricular and ventricular arrhythmias. This drug is an iodine-containing compound that tends to accumulate in several organs, including the lungs. It has been associated with a variety of adverse events. Of these events, the most serious is amiodarone pulmonary toxicity. Although the incidence of this complication has decreased with the use of lower doses of amiodarone, it can occur with any dose. Because amiodarone is widely used, all clinicians should be vigilant of this possibility. Pulmonary toxicity usually manifests as an acute or subacute pneumonitis, typically with diffuse infiltrates on chest x-ray and high-resolution computed tomography. Other, more localized, forms of pulmonary toxicity may occur, including pleural disease, migratory infiltrates, and single or multiple nodules. With early detection, the prognosis is good. Most patients diagnosed promptly respond well to the withdrawal of amiodarone and the administration of corticosteroids, which are usually given for four to 12 months. It is important that physicians be familiar with amiodarone treatment guidelines and follow published recommendations for the monitoring of pulmonary as well as extrapulmonary adverse effects.http://dx.doi.org/10.1155/2009/282540 |
| spellingShingle | Norman Wolkove Marc Baltzan Amiodarone Pulmonary Toxicity Canadian Respiratory Journal |
| title | Amiodarone Pulmonary Toxicity |
| title_full | Amiodarone Pulmonary Toxicity |
| title_fullStr | Amiodarone Pulmonary Toxicity |
| title_full_unstemmed | Amiodarone Pulmonary Toxicity |
| title_short | Amiodarone Pulmonary Toxicity |
| title_sort | amiodarone pulmonary toxicity |
| url | http://dx.doi.org/10.1155/2009/282540 |
| work_keys_str_mv | AT normanwolkove amiodaronepulmonarytoxicity AT marcbaltzan amiodaronepulmonarytoxicity |