Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism

Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism

IntroductionCurcumin has been found to inhibit atherosclerosis. However, its poor stability and low activity severely limit its further application. To overcome the shortcomings of curcumin, our team successfully designed a novel curcumin analog, CACN136. This study aims to explore the anti-atherosc...

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Bibliographic Details
Main Authors: Qianjiao Zhao, Yueting Zhong, Zheng Li, Jia Tang, Chao Pi, Wenwu Zheng, Peng Shi, Ying Zuo, Jun Jiang, Yan Yang, Shifeng Chu, Yumeng Wei, Ling Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
atherosclerosis
curcumin analog
macrophage
M1/M2
lipid metabolism
CACN136
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1632647/full
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