Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

ABSTRACT The SARS-CoV-2 main protease (Mpro) is essential for viral replication and is a primary target for COVID-19 antivirals. Direct-acting antivirals such as nirmatrelvir, the active component of Paxlovid, target the Mpro active site to block viral polyprotein cleavage and thus replication. Howe...

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Main Authors: Sarah N. Zvornicanin, Ala M. Shaqra, Julia Flynn, Heidi Carias Martinez, Weiping Jia, Stephanie Moquin, Dustin Dovala, Daniel N. Bolon, Nese Kurt Yilmaz, Celia A. Schiffer
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
drug resistance mechanisms
protein structure-function
protease inhibitors
antiviral agents
proteolytic enzymes
crystal structure
Online Access:https://journals.asm.org/doi/10.1128/mbio.04068-24
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