Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis
Background Despite the robust evidence demonstrating positive effects from creatine supplementation (primarily when associated with resistance training) on measures of body composition, there is a lack of a comprehensive evaluation regarding the influence of creatine protocol parameters (including d...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of the International Society of Sports Nutrition |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15502783.2024.2380058 |
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| author | Fereshteh Pashayee-Khamene Zeinab Heidari Omid Asbaghi Damoon Ashtary-Larky Kian Goudarzi Scott C Forbes Darren G. Candow Reza Bagheri Matin Ghanavati Fred Dutheil |
| author_facet | Fereshteh Pashayee-Khamene Zeinab Heidari Omid Asbaghi Damoon Ashtary-Larky Kian Goudarzi Scott C Forbes Darren G. Candow Reza Bagheri Matin Ghanavati Fred Dutheil |
| author_sort | Fereshteh Pashayee-Khamene |
| collection | DOAJ |
| description | Background Despite the robust evidence demonstrating positive effects from creatine supplementation (primarily when associated with resistance training) on measures of body composition, there is a lack of a comprehensive evaluation regarding the influence of creatine protocol parameters (including dose and form) on body mass and estimates of fat-free and fat mass.Methods Randomized controlled trials (RCTs) evaluating the effect of creatine supplementation on body composition were included. Electronic databases, including PubMed, Web of Science, and Scopus were searched up to July 2023. Heterogeneity tests were performed. Random effect models were assessed based on the heterogeneity tests, and pooled data were examined to determine the weighted mean difference (WMD) with a 95% confidence interval (CI).Results From 4831 initial records, a total of 143 studies met the inclusion criteria. Creatine supplementation increased body mass (WMD: 0.86 kg; 95% CI: 0.76 to 0.96, I2 = 0%) and fat-free mass (WMD: 0.82 kg; 95% CI: 0.57 to 1.06, I2 = 0%) while reducing body fat percentage (WMD: −0.28 %; 95% CI: −0.47 to −0.09; I2 = 0%). Studies that incorporated a maintenance dose of creatine or performed resistance training in conjunction with supplementation had greater effects on body composition.Conclusion Creatine supplementation has a small effect on body mass and estimates of fat-free mass and body fat percentage. These findings were more robust when combined with resistance training. |
| format | Article |
| id | doaj-art-18b7ef6d26854885a6a44354f26e3240 |
| institution | Kabale University |
| issn | 1550-2783 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj-art-18b7ef6d26854885a6a44354f26e32402024-12-12T06:10:58ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832024-12-0121110.1080/15502783.2024.2380058Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysisFereshteh Pashayee-Khamene0Zeinab Heidari1Omid Asbaghi2Damoon Ashtary-Larky3Kian Goudarzi4Scott C Forbes5Darren G. Candow6Reza Bagheri7Matin Ghanavati8Fred Dutheil9Ahvaz Jundishapur University of Medical Sciences, Student research committee, Ahvaz, IranAhvaz Jundishapur University of Medical Sciences, Student research committee, Ahvaz, IranShahid Beheshti University of Medical Sciences, Cancer Research Center, Tehran, IranAhvaz Jundishapur University of Medical Sciences, Nutrition and Metabolic Diseases Research Center, Ahvaz, IranShahid Beheshti University of Medical Sciences, Faculty of Medicine, Tehran, IranBrandon University, Department of Physical Education Studies, Brandon, MB, CanadaUniversity of Regina, Faculty of Kinesiology and Health Studies, Regina, SK, CanadaUniversity of Isfahan, Department of Exercise Physiology, Isfahan, IranShahid Beheshti University of Medical Sciences, National Nutrition and Food Technology Research Institute, (Faculty of Nutrition Science and Food Technology), Tehran, IranUniversity Hospital of Clermont–Ferrand, Université Clermont Auvergne, CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont–Ferrand, Occupational and Environmental Medicine, Clermont–Ferrand, FranceBackground Despite the robust evidence demonstrating positive effects from creatine supplementation (primarily when associated with resistance training) on measures of body composition, there is a lack of a comprehensive evaluation regarding the influence of creatine protocol parameters (including dose and form) on body mass and estimates of fat-free and fat mass.Methods Randomized controlled trials (RCTs) evaluating the effect of creatine supplementation on body composition were included. Electronic databases, including PubMed, Web of Science, and Scopus were searched up to July 2023. Heterogeneity tests were performed. Random effect models were assessed based on the heterogeneity tests, and pooled data were examined to determine the weighted mean difference (WMD) with a 95% confidence interval (CI).Results From 4831 initial records, a total of 143 studies met the inclusion criteria. Creatine supplementation increased body mass (WMD: 0.86 kg; 95% CI: 0.76 to 0.96, I2 = 0%) and fat-free mass (WMD: 0.82 kg; 95% CI: 0.57 to 1.06, I2 = 0%) while reducing body fat percentage (WMD: −0.28 %; 95% CI: −0.47 to −0.09; I2 = 0%). Studies that incorporated a maintenance dose of creatine or performed resistance training in conjunction with supplementation had greater effects on body composition.Conclusion Creatine supplementation has a small effect on body mass and estimates of fat-free mass and body fat percentage. These findings were more robust when combined with resistance training.https://www.tandfonline.com/doi/10.1080/15502783.2024.2380058Creatine supplementationbody composition indicesmeta-analysis |
| spellingShingle | Fereshteh Pashayee-Khamene Zeinab Heidari Omid Asbaghi Damoon Ashtary-Larky Kian Goudarzi Scott C Forbes Darren G. Candow Reza Bagheri Matin Ghanavati Fred Dutheil Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis Journal of the International Society of Sports Nutrition Creatine supplementation body composition indices meta-analysis |
| title | Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis |
| title_full | Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis |
| title_fullStr | Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis |
| title_full_unstemmed | Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis |
| title_short | Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis |
| title_sort | creatine supplementation protocols with or without training interventions on body composition a grade assessed systematic review and dose response meta analysis |
| topic | Creatine supplementation body composition indices meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/15502783.2024.2380058 |
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