MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the deposition of immune complexes due to widespread loss of immune tolerance to nuclear self-antigens. Deposition in the renal glomeruli results in the development of lupus nephritis (LN), the leading cause of morbidity an...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/430239 |
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| author | Cristen B. Chafin Christopher M. Reilly |
| author_facet | Cristen B. Chafin Christopher M. Reilly |
| author_sort | Cristen B. Chafin |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the deposition of immune complexes due to widespread loss of immune tolerance to nuclear self-antigens. Deposition in the renal glomeruli results in the development of lupus nephritis (LN), the leading cause of morbidity and mortality in SLE. In addition to the well-recognized genetic susceptibility to SLE, disease pathogenesis is influenced by epigenetic regulators such as microRNAs (miRNAs). miRNAs are small, noncoding RNAs that bind to the 3′ untranslated region of target mRNAs resulting in posttranscriptional gene modulation. miRNAs play an important and dynamic role in the activation of innate immune cells and are critical in regulating the adaptive immune response. Immune stimulation and the resulting cytokine milieu alter miRNA expression while miRNAs themselves modify cellular responses to stimulation. Here we examine dysregulated miRNAs implicated in LN pathogenesis from human SLE patients and murine lupus models. The effects of LN-associated miRNAs in the kidney, peripheral blood mononuclear cells, macrophages, mesangial cells, dendritic cells, and splenocytes are discussed. As the role of miRNAs in immunopathogenesis becomes delineated, it is likely that specific miRNAs may serve as targets for therapeutic intervention in the treatment of LN and other pathologies. |
| format | Article |
| id | doaj-art-18b2f796a28843f695e69f8c9fd2fee8 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-18b2f796a28843f695e69f8c9fd2fee82025-08-20T02:02:12ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/430239430239MicroRNAs Implicated in the Immunopathogenesis of Lupus NephritisCristen B. Chafin0Christopher M. Reilly1Department of Biomedical Sciences & Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USADepartment of Biomedical Sciences & Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USASystemic lupus erythematosus (SLE) is an autoimmune disease characterized by the deposition of immune complexes due to widespread loss of immune tolerance to nuclear self-antigens. Deposition in the renal glomeruli results in the development of lupus nephritis (LN), the leading cause of morbidity and mortality in SLE. In addition to the well-recognized genetic susceptibility to SLE, disease pathogenesis is influenced by epigenetic regulators such as microRNAs (miRNAs). miRNAs are small, noncoding RNAs that bind to the 3′ untranslated region of target mRNAs resulting in posttranscriptional gene modulation. miRNAs play an important and dynamic role in the activation of innate immune cells and are critical in regulating the adaptive immune response. Immune stimulation and the resulting cytokine milieu alter miRNA expression while miRNAs themselves modify cellular responses to stimulation. Here we examine dysregulated miRNAs implicated in LN pathogenesis from human SLE patients and murine lupus models. The effects of LN-associated miRNAs in the kidney, peripheral blood mononuclear cells, macrophages, mesangial cells, dendritic cells, and splenocytes are discussed. As the role of miRNAs in immunopathogenesis becomes delineated, it is likely that specific miRNAs may serve as targets for therapeutic intervention in the treatment of LN and other pathologies.http://dx.doi.org/10.1155/2013/430239 |
| spellingShingle | Cristen B. Chafin Christopher M. Reilly MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis Clinical and Developmental Immunology |
| title | MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis |
| title_full | MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis |
| title_fullStr | MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis |
| title_full_unstemmed | MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis |
| title_short | MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis |
| title_sort | micrornas implicated in the immunopathogenesis of lupus nephritis |
| url | http://dx.doi.org/10.1155/2013/430239 |
| work_keys_str_mv | AT cristenbchafin micrornasimplicatedintheimmunopathogenesisoflupusnephritis AT christophermreilly micrornasimplicatedintheimmunopathogenesisoflupusnephritis |