Spatial recognition and semi-quantification of epigenetic events in pancreatic cancer subtypes with multiplexed molecular imaging and machine learning

Spatial recognition and semi-quantification of epigenetic events in pancreatic cancer subtypes with multiplexed molecular imaging and machine learning

Abstract Genomic alterations are the driving force behind pancreatic cancer (PC) tumorigenesis, but they do not fully account for its diverse phenotypes. Investigating the epigenetic landscapes of PC offers a more comprehensive understanding and could identify targeted therapies that enhance patient...

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Bibliographic Details
Main Authors: Krzysztof Szymoński, Natalia Janiszewska, Kamila Sofińska, Katarzyna Skirlińska-Nosek, Dawid Lupa, Michał Czaja, Marta Urbańska, Katarzyna Jurkowska, Kamila Konik, Marta Olszewska, Dariusz Adamek, Kamil Awsiuk, Ewelina Lipiec
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Spatial epigenomics
Epigenetic modifications
DNA conformation
Z-DNA
Pancreatic cancer
Molecular imaging
Online Access:https://doi.org/10.1038/s41598-025-90087-z
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