Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial
Abstract Parkinson’s disease (PD) is characterized by motor fluctuations, with alternating periods of good (“ON”) and poor (“OFF”) motor function. Monitoring these fluctuations is crucial for optimizing treatment, yet traditional methods rely on subjective patient reports. This multicenter, single-b...
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Nature Portfolio
2025-08-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00977-2 |
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| author | Alejandro Rodríguez-Molinero Carlos Pérez-López Nuria Caballol Mariateresa Buongiorno María Asunción Ávila Rivera Núria López Ariztegui Lydia López-Manzanares Jorge Hernández-Vara Àngels Bayes-Rusiñol Alexandre Gironell Carreró María Álvarez Saúco Elisabet Franquet Gomez David A. Pérez-Martínez Sonia Escalante Arroyo Silvia Martí-Martínez Pablo Mir José Mª Salom Juan Juan Carlos Martínez-Castrillo Cristian Tebé On behalf of the MoMoPa-EC Research Group |
| author_facet | Alejandro Rodríguez-Molinero Carlos Pérez-López Nuria Caballol Mariateresa Buongiorno María Asunción Ávila Rivera Núria López Ariztegui Lydia López-Manzanares Jorge Hernández-Vara Àngels Bayes-Rusiñol Alexandre Gironell Carreró María Álvarez Saúco Elisabet Franquet Gomez David A. Pérez-Martínez Sonia Escalante Arroyo Silvia Martí-Martínez Pablo Mir José Mª Salom Juan Juan Carlos Martínez-Castrillo Cristian Tebé On behalf of the MoMoPa-EC Research Group |
| author_sort | Alejandro Rodríguez-Molinero |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is characterized by motor fluctuations, with alternating periods of good (“ON”) and poor (“OFF”) motor function. Monitoring these fluctuations is crucial for optimizing treatment, yet traditional methods rely on subjective patient reports. This multicenter, single-blind, cluster-randomized trial evaluated the effectiveness of three monitoring approaches in real-world clinical practice. Neurologists from 35 centers were randomized into three groups: one using clinical visit data alone, another incorporating Hauser diary entries, and a third integrating Parkinson’s Holter (STAT-ON®) reports. A total of 156 patients were recruited. Changes in ‘OFF time’ from baseline to 26 weeks were minimal and non-significant across groups. Secondary outcomes, including ‘ON time,’ dyskinesia, and quality-of-life scores, showed no significant differences. These findings suggest that the choice of motor fluctuation monitoring method may not significantly impact clinical outcomes, underscoring the need for a broader understanding of how these monitoring tools are integrated and utilized in real-world settings. Trial registration: NCT04176302 (November 21, 2019 - ClinicalTrials.gov). |
| format | Article |
| id | doaj-art-18a9ed9648764f7fa4976bd2e1a8c72e |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-18a9ed9648764f7fa4976bd2e1a8c72e2025-08-24T11:14:40ZengNature Portfolionpj Parkinson's Disease2373-80572025-08-011111910.1038/s41531-025-00977-2Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trialAlejandro Rodríguez-Molinero0Carlos Pérez-López1Nuria Caballol2Mariateresa Buongiorno3María Asunción Ávila Rivera4Núria López Ariztegui5Lydia López-Manzanares6Jorge Hernández-Vara7Àngels Bayes-Rusiñol8Alexandre Gironell Carreró9María Álvarez Saúco10Elisabet Franquet Gomez11David A. Pérez-Martínez12Sonia Escalante Arroyo13Silvia Martí-Martínez14Pablo Mir15José Mª Salom Juan16Juan Carlos Martínez-Castrillo17Cristian Tebé18On behalf of the MoMoPa-EC Research GroupÀrea de Recerca, Consorci Sanitari de l’Alt Penedès i GarrafÀrea de Recerca, Consorci Sanitari de l’Alt Penedès i GarrafDepartment of Neurology, Complex Hospitalari Universitari Moisès BroggiDepartment of Neurology , Hospital Universitari Vall d’HebronDepartment of Neurology, Complex Hospitalari Universitari Moisès BroggiDepartment of Neurology, Hospital Universitario de ToledoDepartment of Neurology, Hospital Universitario de la PrincesaDepartment of Neurology , Hospital Universitari Vall d’HebronParkinson’s and Movement Disorders Unit, Hospital Quirón-TeknonDepartment of Neurology, Hospital de la Santa Creu i Sant PauDepartment of Neurology, Hospital general de ElcheDepartment of Neurology, Hospital Sant Camil. Sant Pere de RibesDepartment of Neurology, Hospital Universitario 12 de OctubreDepartment of Neurology, Hospital de Tortosa Verge de la CintaDepartment of Neurology, Hospital General de AlicanteUnidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaDepartment of Neurology, Hospital Clínico de ValenciaMovement Disorders and Neurodegenerative Diseases Unit, IRYCIS, Hospital Ramón y CajalBiostatistics Support and Research Unit, Germans Trias I Pujol Research Institute and Hospital (IGTP), BarcelonaAbstract Parkinson’s disease (PD) is characterized by motor fluctuations, with alternating periods of good (“ON”) and poor (“OFF”) motor function. Monitoring these fluctuations is crucial for optimizing treatment, yet traditional methods rely on subjective patient reports. This multicenter, single-blind, cluster-randomized trial evaluated the effectiveness of three monitoring approaches in real-world clinical practice. Neurologists from 35 centers were randomized into three groups: one using clinical visit data alone, another incorporating Hauser diary entries, and a third integrating Parkinson’s Holter (STAT-ON®) reports. A total of 156 patients were recruited. Changes in ‘OFF time’ from baseline to 26 weeks were minimal and non-significant across groups. Secondary outcomes, including ‘ON time,’ dyskinesia, and quality-of-life scores, showed no significant differences. These findings suggest that the choice of motor fluctuation monitoring method may not significantly impact clinical outcomes, underscoring the need for a broader understanding of how these monitoring tools are integrated and utilized in real-world settings. Trial registration: NCT04176302 (November 21, 2019 - ClinicalTrials.gov).https://doi.org/10.1038/s41531-025-00977-2 |
| spellingShingle | Alejandro Rodríguez-Molinero Carlos Pérez-López Nuria Caballol Mariateresa Buongiorno María Asunción Ávila Rivera Núria López Ariztegui Lydia López-Manzanares Jorge Hernández-Vara Àngels Bayes-Rusiñol Alexandre Gironell Carreró María Álvarez Saúco Elisabet Franquet Gomez David A. Pérez-Martínez Sonia Escalante Arroyo Silvia Martí-Martínez Pablo Mir José Mª Salom Juan Juan Carlos Martínez-Castrillo Cristian Tebé On behalf of the MoMoPa-EC Research Group Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial npj Parkinson's Disease |
| title | Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_full | Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_fullStr | Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_full_unstemmed | Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_short | Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_sort | parkinson s disease medication adjustments based on wearable device information compared to other methods randomized clinical trial |
| url | https://doi.org/10.1038/s41531-025-00977-2 |
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