Advancing syphilis diagnosis: multi-phase study evaluation of a TpN17-based double-antigen sandwich ELISA for detecting Treponema pallidum specific antibodies

Advancing syphilis diagnosis: multi-phase study evaluation of a TpN17-based double-antigen sandwich ELISA for detecting Treponema pallidum specific antibodies

Syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum, has high incidence rates among adults, pregnant women, and newborns. Diagnostic procedures typically involve a treponemal test (such as ELISA, CMIA, and IFI), followed by a non-treponemal test (VDRL and RPR). This...

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Main Authors: Ângelo Antônio Oliveira Silva, Larissa Carvalho Medrado Vasconcelos, Natália Erdens Maron Freitas, Talita Andrade Oliva, Miralba Freire Carvalho Ribeiro Silva, Isadora Cristina Siqueira, Edimilson Domingos Silva, Keila Gisele Azevedo Figueiredo Santos, Maria Amélia Virgens Lima, Nilson Ivo Tonin Zanchin, Fred Luciano Neves Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
syphilis
treponemal test
recombinant protein
TpN17
DAgS-ELISA
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1572785/full
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