Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region
Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investiga...
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Endocrinology Research Centre
2015-03-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6697 |
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| author | Irina Arkad'evna Bondar Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexeevna Sokolova |
| author_facet | Irina Arkad'evna Bondar Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexeevna Sokolova |
| author_sort | Irina Arkad'evna Bondar |
| collection | DOAJ |
| description | Aim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region. Materials and Methods. 326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219) and ABCC8 (rs757110) was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia). Results. Patients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8?9.1 years vs. 61.6?7.9 years, p |
| format | Article |
| id | doaj-art-189f1a564a9e4b3e9653436ebe3fc7fb |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-189f1a564a9e4b3e9653436ebe3fc7fb2025-08-20T03:47:53ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782015-03-01181424710.14341/DM2015142-476559Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk regionIrina Arkad'evna Bondar0Maksim Leonidovich Filipenko1Olesya Yur'evna Shabel'nikova2Ekaterina Alexeevna Sokolova3Novosibirsk State Medical University, NovosibirskInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk; Novosibirsk State University, NovosibirskInstitute of Chemical Biology and Fundamental Medicine, Novosibirsk; Novosibirsk State University, NovosibirskNovosibirsk State Medical University, Novosibirsk; Novosibirsk State Regional Hospital, NovosibirskAim. Sulfonylureas (SU) are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM). There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region. Materials and Methods. 326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219) and ABCC8 (rs757110) was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia). Results. Patients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8?9.1 years vs. 61.6?7.9 years, phttps://www.dia-endojournals.ru/jour/article/view/6697type 2 diabetes mellituspharmacogenomicsinsulin resistancesulfonylureaskcnj11 (rs5219)abcc8 (rs757110) |
| spellingShingle | Irina Arkad'evna Bondar Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexeevna Sokolova Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region Сахарный диабет type 2 diabetes mellitus pharmacogenomics insulin resistance sulfonylureas kcnj11 (rs5219) abcc8 (rs757110) |
| title | Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region |
| title_full | Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region |
| title_fullStr | Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region |
| title_full_unstemmed | Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region |
| title_short | Lack of association between KCNJ11 (rs5219) and ABCC8 (rs757110) polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region |
| title_sort | lack of association between kcnj11 rs5219 and abcc8 rs757110 polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in novosibirsk region |
| topic | type 2 diabetes mellitus pharmacogenomics insulin resistance sulfonylureas kcnj11 (rs5219) abcc8 (rs757110) |
| url | https://www.dia-endojournals.ru/jour/article/view/6697 |
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