Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
Melamine, its analogues, and aromatic amines (AAs) were commonly detected in a previous study of pregnant women in the Environmental influences on Child Health Outcomes (ECHO) Cohort. While these chemicals have identified toxicities, little is known about their influences on fetal development. We me...
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Elsevier
2025-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024008146 |
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| author | Giehae Choi Xiaoshuang Xun Deborah H. Bennett John D. Meeker Rachel Morello-Frosch Sheela Sathyanarayana Susan L Schantz Leonardo Trasande Deborah Watkins Edo D. Pellizzari Wenlong Li Kurunthachalam Kannan Tracey J. Woodruff Jessie P. Buckley |
| author_facet | Giehae Choi Xiaoshuang Xun Deborah H. Bennett John D. Meeker Rachel Morello-Frosch Sheela Sathyanarayana Susan L Schantz Leonardo Trasande Deborah Watkins Edo D. Pellizzari Wenlong Li Kurunthachalam Kannan Tracey J. Woodruff Jessie P. Buckley |
| author_sort | Giehae Choi |
| collection | DOAJ |
| description | Melamine, its analogues, and aromatic amines (AAs) were commonly detected in a previous study of pregnant women in the Environmental influences on Child Health Outcomes (ECHO) Cohort. While these chemicals have identified toxicities, little is known about their influences on fetal development. We measured these chemicals in gestational urine samples in 3 ECHO cohort sites to assess associations with birth outcomes (n = 1,231). We estimated beta coefficients and 95% confidence intervals (CIs) using adjusted linear mixed models with continuous dilution-standardized concentrations (log2 transformed and scaled by interquartile range, IQR) or binary indicators for detection. As secondary analyses, we repeated analyses using categorical outcomes. Forty-one of 45 analytes were detected in at least one sample, with > 95 % detection of melamine, cyanuric acid, ammelide, and aniline. Higher melamine concentration was associated with longer gestational age (β^ per IQR increase of log2-transformed: 0.082 [95 % CI: −0.012, 0.177]; 2nd vs 1st tertile: 0.173 [-0.048, 0.394]; 3rd vs 1st tertile: 0.186 [-0.035, 0.407]). Similarly in secondary analyses using categorical outcomes, an IQR increase in log2(melamine) was associated with 1.22 [0.99, 1.50] higher odds of post-term (>40 & ≤42 weeks) as compared to full-term (≥38 & ≤40 weeks). Several AAs were associated with birthweight and gestational length, with the direction of associations varying by AA. Some stronger associations were observed in females. Our findings suggest melamine and its analogs and AAs may influence gestational length and birthweight. |
| format | Article |
| id | doaj-art-18986e917db7471e9aa655b245843791 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-18986e917db7471e9aa655b2458437912025-01-24T04:44:07ZengElsevierEnvironment International0160-41202025-01-01195109227Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO CohortGiehae Choi0Xiaoshuang Xun1Deborah H. Bennett2John D. Meeker3Rachel Morello-Frosch4Sheela Sathyanarayana5Susan L Schantz6Leonardo Trasande7Deborah Watkins8Edo D. Pellizzari9Wenlong Li10Kurunthachalam Kannan11Tracey J. Woodruff12Jessie P. Buckley13Department of Environmental Health and Engineering, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, United StatesDepartment of Epidemiology, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, United StatesDepartment of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, United StatesDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, United StatesSchool of Public Health and Department of Environmental Science, Policy and Management, University of California, Berkeley, Mulford Hall, 130 Hilgard Way, Berkeley, CA 94720, United StatesDepartment of Pediatrics and Environmental and Occupational Health Sciences, University of Washington, 3980 15th Ave NE, Seattle, WA 98195, United States; Seattle Children’s Research Institute, 1900 9th Ave, Seattle, WA 98101, United StatesBeckman Institute for Advanced Science and Technology and Department of Comparative Biosciences, University of Illinois Urbana-Champaign, Urbana, IL 61802, United StatesDepartments of Pediatrics and Population Health, NYU Grossman School of Medicine, and NYU Wagner School of Pediatrics, 550 1st Ave., New York, NY 10016, United StatesDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, United StatesFellow Program, Research Triangle Institute, 3040 E Cornwallis Rd, Research Triangle Park, NC 27709, United StatesWadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, United StatesWadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, United StatesDepartment of Obstetrics, Gynecology, and Reproductive Sciences and the Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, 550 16th Street, Box 0132, San Francisco, CA 94158, United States; Corresponding authors.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, CB#7435, Chapel Hill, NC 27599-7435, United States; Corresponding authors.Melamine, its analogues, and aromatic amines (AAs) were commonly detected in a previous study of pregnant women in the Environmental influences on Child Health Outcomes (ECHO) Cohort. While these chemicals have identified toxicities, little is known about their influences on fetal development. We measured these chemicals in gestational urine samples in 3 ECHO cohort sites to assess associations with birth outcomes (n = 1,231). We estimated beta coefficients and 95% confidence intervals (CIs) using adjusted linear mixed models with continuous dilution-standardized concentrations (log2 transformed and scaled by interquartile range, IQR) or binary indicators for detection. As secondary analyses, we repeated analyses using categorical outcomes. Forty-one of 45 analytes were detected in at least one sample, with > 95 % detection of melamine, cyanuric acid, ammelide, and aniline. Higher melamine concentration was associated with longer gestational age (β^ per IQR increase of log2-transformed: 0.082 [95 % CI: −0.012, 0.177]; 2nd vs 1st tertile: 0.173 [-0.048, 0.394]; 3rd vs 1st tertile: 0.186 [-0.035, 0.407]). Similarly in secondary analyses using categorical outcomes, an IQR increase in log2(melamine) was associated with 1.22 [0.99, 1.50] higher odds of post-term (>40 & ≤42 weeks) as compared to full-term (≥38 & ≤40 weeks). Several AAs were associated with birthweight and gestational length, with the direction of associations varying by AA. Some stronger associations were observed in females. Our findings suggest melamine and its analogs and AAs may influence gestational length and birthweight.http://www.sciencedirect.com/science/article/pii/S0160412024008146MelamineCyanuric acidAromatic aminesGestational ageBirthweightPreterm birth |
| spellingShingle | Giehae Choi Xiaoshuang Xun Deborah H. Bennett John D. Meeker Rachel Morello-Frosch Sheela Sathyanarayana Susan L Schantz Leonardo Trasande Deborah Watkins Edo D. Pellizzari Wenlong Li Kurunthachalam Kannan Tracey J. Woodruff Jessie P. Buckley Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort Environment International Melamine Cyanuric acid Aromatic amines Gestational age Birthweight Preterm birth |
| title | Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort |
| title_full | Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort |
| title_fullStr | Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort |
| title_full_unstemmed | Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort |
| title_short | Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort |
| title_sort | associations of prenatal urinary melamine melamine analogues and aromatic amines with gestational duration and fetal growth in the echo cohort |
| topic | Melamine Cyanuric acid Aromatic amines Gestational age Birthweight Preterm birth |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024008146 |
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