Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients
Abstract Streptococcus pneumoniae (SP) remains an important cause of community acquired pneumonia (CAP). We aimed to describe the prevalence and characteristics of outpatients with radiologically confirmed pneumococcal CAP. Between November 2017 and December 2019, a French network of general practit...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Primary Care Respiratory Medicine |
| Online Access: | https://doi.org/10.1038/s41533-024-00405-7 |
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| author | Josselin Le Bel Juliette Pinot Toni Alfaiate Marie Ecollan Fanny Cussac Raphaël Pecqueur Marie-Pierre Revel Cyrille Vartanian Emmanuelle Varon Christian Theilacker Xavier Duval Henri Partouche Cédric Laouénan Serge Gilberg |
| author_facet | Josselin Le Bel Juliette Pinot Toni Alfaiate Marie Ecollan Fanny Cussac Raphaël Pecqueur Marie-Pierre Revel Cyrille Vartanian Emmanuelle Varon Christian Theilacker Xavier Duval Henri Partouche Cédric Laouénan Serge Gilberg |
| author_sort | Josselin Le Bel |
| collection | DOAJ |
| description | Abstract Streptococcus pneumoniae (SP) remains an important cause of community acquired pneumonia (CAP). We aimed to describe the prevalence and characteristics of outpatients with radiologically confirmed pneumococcal CAP. Between November 2017 and December 2019, a French network of general practitioners enrolled CAP-suspected adults, with ≥1 clinical signs of infection and ≥1 signs of pulmonary localization in an observational study. Pneumococcal CAP was defined by the combination of a chest X-ray (CXR) compatible with CAP and SP detection by any of four microbiological tests (blood culture, sputum culture, pneumococcal urinary antigen test [BinaxNow®] and serotype-specific multiplex urinary antigen detection test [Pfizer Inc®]. To identify other pathogens, next to cultures, nasopharyngeal multiplex PCR was performed. Three hundred and forty-eight patients were included, of whom 144 had a positive CXR, 135/144 (93.8%) had not received antibiotics prior to inclusion, 21/144 (14.6%) had ≥1 positive microbiological test for SP, and 66/144 (45.8%) were negative for all four microbiological tests and were considered as non-pneumococcal CAP. Pneumococcal serotypes were identified for 12 patients. This study assessing the prevalence of SP among CAP outpatients using comprehensive microbiologic testing shows that SP is still the most frequently identified microorganism. |
| format | Article |
| id | doaj-art-187d02c15f0f4c8c9fa7bb0c2c81fc57 |
| institution | Kabale University |
| issn | 2055-1010 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Primary Care Respiratory Medicine |
| spelling | doaj-art-187d02c15f0f4c8c9fa7bb0c2c81fc572025-01-05T12:09:01ZengNature Portfolionpj Primary Care Respiratory Medicine2055-10102025-01-013511810.1038/s41533-024-00405-7Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatientsJosselin Le Bel0Juliette Pinot1Toni Alfaiate2Marie Ecollan3Fanny Cussac4Raphaël Pecqueur5Marie-Pierre Revel6Cyrille Vartanian7Emmanuelle Varon8Christian Theilacker9Xavier Duval10Henri Partouche11Cédric Laouénan12Serge Gilberg13Université Paris Cité, Department of general practice, Paris, FranceUniversité Paris Cité, Department of general practice, Paris, FranceDepartment of Epidemiology Biostatistics and Clinical Research, AP-HP, Hôpital Bichat, Paris, FranceUniversité Paris Cité, Department of general practice, Paris, FranceUniversité Paris Cité, Department of general practice, Paris, FranceUniversité Paris Cité, Department of general practice, Paris, FranceDepartment of Radiology, Hôpital Cochin, AP-HP Centre, Paris, FranceDepartment of general practice, Faculty of Medicine, University of Nantes, France - NantesCentre National de Référence des Pneumocoques, Centre Hospitalier Intercommunal de Créteil, Créteil, FrancePfizer VaccinesUniversité Paris Cité, IAME, INSERMUniversité Paris Cité, Department of general practice, Paris, FranceUniversité Paris Cité, IAME, INSERMUniversité Paris Cité, Department of general practice, Paris, FranceAbstract Streptococcus pneumoniae (SP) remains an important cause of community acquired pneumonia (CAP). We aimed to describe the prevalence and characteristics of outpatients with radiologically confirmed pneumococcal CAP. Between November 2017 and December 2019, a French network of general practitioners enrolled CAP-suspected adults, with ≥1 clinical signs of infection and ≥1 signs of pulmonary localization in an observational study. Pneumococcal CAP was defined by the combination of a chest X-ray (CXR) compatible with CAP and SP detection by any of four microbiological tests (blood culture, sputum culture, pneumococcal urinary antigen test [BinaxNow®] and serotype-specific multiplex urinary antigen detection test [Pfizer Inc®]. To identify other pathogens, next to cultures, nasopharyngeal multiplex PCR was performed. Three hundred and forty-eight patients were included, of whom 144 had a positive CXR, 135/144 (93.8%) had not received antibiotics prior to inclusion, 21/144 (14.6%) had ≥1 positive microbiological test for SP, and 66/144 (45.8%) were negative for all four microbiological tests and were considered as non-pneumococcal CAP. Pneumococcal serotypes were identified for 12 patients. This study assessing the prevalence of SP among CAP outpatients using comprehensive microbiologic testing shows that SP is still the most frequently identified microorganism.https://doi.org/10.1038/s41533-024-00405-7 |
| spellingShingle | Josselin Le Bel Juliette Pinot Toni Alfaiate Marie Ecollan Fanny Cussac Raphaël Pecqueur Marie-Pierre Revel Cyrille Vartanian Emmanuelle Varon Christian Theilacker Xavier Duval Henri Partouche Cédric Laouénan Serge Gilberg Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients npj Primary Care Respiratory Medicine |
| title | Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients |
| title_full | Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients |
| title_fullStr | Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients |
| title_full_unstemmed | Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients |
| title_short | Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients |
| title_sort | description and characterization of pneumococcal community acquired pneumonia cap among radiologically confirmed cap in outpatients |
| url | https://doi.org/10.1038/s41533-024-00405-7 |
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