Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved]
Background Over 250 million children are developing sub-optimally due to their exposure to early life adversities. While previous studies have examined the independent effects of nutritional status, psychosocial adversities, and environmental pollutants on children’s outcomes, little is known about...
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Wellcome
2024-11-01
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| Online Access: | https://wellcomeopenresearch.org/articles/9-486/v2 |
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| author | Eunice Lobo Jyothi S. Menon Deepa R. Supriya Bhavnani Onno CP van Schayck Shweta Dixit Prashanth Nuggehalli Srinivas Aditi Roy Sumathi Swaminathan Ruby Gupta Poornima Prabhakaran Prashanth Thankachan Giridhara Rathnaiah Babu Debarati Mukherjee Siddhartha Mandal Gauri Divan |
| author_facet | Eunice Lobo Jyothi S. Menon Deepa R. Supriya Bhavnani Onno CP van Schayck Shweta Dixit Prashanth Nuggehalli Srinivas Aditi Roy Sumathi Swaminathan Ruby Gupta Poornima Prabhakaran Prashanth Thankachan Giridhara Rathnaiah Babu Debarati Mukherjee Siddhartha Mandal Gauri Divan |
| author_sort | Eunice Lobo |
| collection | DOAJ |
| description | Background Over 250 million children are developing sub-optimally due to their exposure to early life adversities. While previous studies have examined the independent effects of nutritional status, psychosocial adversities, and environmental pollutants on children’s outcomes, little is known about their interaction and cumulative effects. Objectives This study aims to investigate the independent, interaction, and cumulative effects of nutritional, psychosocial, and environmental factors on children’s cognitive development and mental health in urban and rural India. It also seeks to explain pathways leading to inequities in child outcomes at the individual, household, and neighbourhood levels. Methods A mixed-methods prospective cohort study will be conducted on 1600 caregiver-child dyads (child age 3–10 years) in urban and rural India. Nutritional status, psychosocial adversities, environmental pollutants, and child mental health outcomes will be assessed using parent-report questionnaires. Performance-based measures will be used to assess cognitive outcomes. Venous blood and urine samples will be used to measure nutritional and pesticide biomarkers in 500 children. Indoor air pollution will be monitored in 200 households twice, during two seasons. Multilevel regression, weighted quantile sum regression, and Bayesian kernel machine regression will assess the individual and combined effects of exposures on child outcomes. Thematic analysis of in-depth interviews and focus group discussions will explore pathways to middle-and late childhood development inequities. Discussion The data will be used to formulate a Theory of Change (ToC) to explain the biological, psychosocial, and environmental origins of children’s cognitive and mental health outcomes across the first decade of life in diverse Indian settings, which can inform interventions targets for promoting children’s outcomes beyond the first 1000 days, potentially generalizable to similar under-resourced global settings. The COINCIDE research infrastructure will comprise a valuable global health resource, including prospective cohort data, validated study tools, and stored biological and environmental samples for future studies. |
| format | Article |
| id | doaj-art-1879c554d2b142e5bdafcb3a01242c6c |
| institution | Kabale University |
| issn | 2398-502X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wellcome |
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| series | Wellcome Open Research |
| spelling | doaj-art-1879c554d2b142e5bdafcb3a01242c6c2025-01-29T01:00:00ZengWellcomeWellcome Open Research2398-502X2024-11-01925783Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved]Eunice Lobo0https://orcid.org/0000-0002-0621-9295Jyothi S. Menon1Deepa R.2Supriya Bhavnani3https://orcid.org/0000-0002-0855-2139Onno CP van Schayck4Shweta Dixit5Prashanth Nuggehalli Srinivas6https://orcid.org/0000-0003-0968-0826Aditi Roy7Sumathi Swaminathan8https://orcid.org/0000-0002-4006-1049Ruby Gupta9Poornima Prabhakaran10Prashanth Thankachan11Giridhara Rathnaiah Babu12https://orcid.org/0000-0003-4370-8933Debarati Mukherjee13https://orcid.org/0000-0003-3473-6537Siddhartha Mandal14Gauri Divan15https://orcid.org/0000-0001-6212-8358Indian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, IndiaCentre for Chronic Disease Control, New Delhi, IndiaIndian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, IndiaChild Development Group, Sangath, New Delhi, IndiaFamily Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Limburg, The NetherlandsCentre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University, Sonipat, IndiaInstitute of Public Health Bengaluru, Bengaluru, Karnataka, IndiaCentre for Chronic Disease Control, New Delhi, IndiaDivision of Nutrition, St. John's Research Institute, Bangalore, IndiaCentre for Chronic Disease Control, New Delhi, IndiaCentre for Chronic Disease Control, New Delhi, IndiaDivision of Nutrition, St. John's Research Institute, Bangalore, IndiaDepartment of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, QatarIndian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, IndiaCentre for Chronic Disease Control, New Delhi, IndiaChild Development Group, Sangath, New Delhi, IndiaBackground Over 250 million children are developing sub-optimally due to their exposure to early life adversities. While previous studies have examined the independent effects of nutritional status, psychosocial adversities, and environmental pollutants on children’s outcomes, little is known about their interaction and cumulative effects. Objectives This study aims to investigate the independent, interaction, and cumulative effects of nutritional, psychosocial, and environmental factors on children’s cognitive development and mental health in urban and rural India. It also seeks to explain pathways leading to inequities in child outcomes at the individual, household, and neighbourhood levels. Methods A mixed-methods prospective cohort study will be conducted on 1600 caregiver-child dyads (child age 3–10 years) in urban and rural India. Nutritional status, psychosocial adversities, environmental pollutants, and child mental health outcomes will be assessed using parent-report questionnaires. Performance-based measures will be used to assess cognitive outcomes. Venous blood and urine samples will be used to measure nutritional and pesticide biomarkers in 500 children. Indoor air pollution will be monitored in 200 households twice, during two seasons. Multilevel regression, weighted quantile sum regression, and Bayesian kernel machine regression will assess the individual and combined effects of exposures on child outcomes. Thematic analysis of in-depth interviews and focus group discussions will explore pathways to middle-and late childhood development inequities. Discussion The data will be used to formulate a Theory of Change (ToC) to explain the biological, psychosocial, and environmental origins of children’s cognitive and mental health outcomes across the first decade of life in diverse Indian settings, which can inform interventions targets for promoting children’s outcomes beyond the first 1000 days, potentially generalizable to similar under-resourced global settings. The COINCIDE research infrastructure will comprise a valuable global health resource, including prospective cohort data, validated study tools, and stored biological and environmental samples for future studies.https://wellcomeopenresearch.org/articles/9-486/v2nutrition early-life stress air pollution pesticide cognitive development child mental healtheng |
| spellingShingle | Eunice Lobo Jyothi S. Menon Deepa R. Supriya Bhavnani Onno CP van Schayck Shweta Dixit Prashanth Nuggehalli Srinivas Aditi Roy Sumathi Swaminathan Ruby Gupta Poornima Prabhakaran Prashanth Thankachan Giridhara Rathnaiah Babu Debarati Mukherjee Siddhartha Mandal Gauri Divan Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] Wellcome Open Research nutrition early-life stress air pollution pesticide cognitive development child mental health eng |
| title | Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] |
| title_full | Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] |
| title_fullStr | Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] |
| title_full_unstemmed | Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] |
| title_short | Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] |
| title_sort | protocol of the nutritional psychosocial and environmental determinants of neurodevelopment and child mental health coincide study version 2 peer review 2 approved |
| topic | nutrition early-life stress air pollution pesticide cognitive development child mental health eng |
| url | https://wellcomeopenresearch.org/articles/9-486/v2 |
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