New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study
Background: Diabetes Mellitus is one of the most common comorbidities in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, data on the incidence of Diabetes Mellitus among adults as post-COVID sequelae has been limited, and this study aims to determine the incidenc...
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Elsevier
2025-01-01
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| Series: | Clinical Epidemiology and Global Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398424003944 |
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| author | Venkatachalam Jayaseelan Sitanshu Sekhar Kar Mahadevan Duraiswamy Manju Rajaram Vikas Menon Mukta Wyawahare D.R. Veda Priya Ravivarman Lakshmanasamy Vanessa Ravel Renjana Sivaji |
| author_facet | Venkatachalam Jayaseelan Sitanshu Sekhar Kar Mahadevan Duraiswamy Manju Rajaram Vikas Menon Mukta Wyawahare D.R. Veda Priya Ravivarman Lakshmanasamy Vanessa Ravel Renjana Sivaji |
| author_sort | Venkatachalam Jayaseelan |
| collection | DOAJ |
| description | Background: Diabetes Mellitus is one of the most common comorbidities in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, data on the incidence of Diabetes Mellitus among adults as post-COVID sequelae has been limited, and this study aims to determine the incidence and the associated factors of Diabetes Mellitus among adults who had COVID-19 infection. Methods: This prospective cohort study was carried out among COVID–19 symptomatic (moderate and severe) and asymptomatic cases admitted or reported in a tertiary care hospital in Puducherry, India. Participants were recruited between May and December 2022. It includes socio-demographic details and follow-up data on clinical symptoms and blood sugar levels for 724 participants without a prior history of Diabetes Mellitus, with 362 in the exposed group and 362 in the comparison group for incidence of Diabetes Mellitus, followed-up for 3 months. Results: Among the study participants, the relative risk of developing Diabetes Mellitus was 2.83 (95 % CI: 1.98–4.06) for the exposed group (moderate/severe cases) compared to the comparison group (mild/asymptomatic). Multivariable analysis further confirmed a relative risk of 2.01 (95 % CI: 1.26–3.20, p = 0.003) for moderate/severe COVID-19 cases, with significant associations for age, smoking, and comorbidities. Conclusion: By the 3rd month, new-onset Diabetes Mellitus was significantly higher in moderate to severe COVID-19 cases. Older age, smoking, and comorbidities were key factors. These findings highlight the need for closer monitoring of severe COVID-19 patients for new-onset diabetes in the post-COVID period. |
| format | Article |
| id | doaj-art-1869098639f14d60a49bd2ddd84ccd22 |
| institution | Kabale University |
| issn | 2213-3984 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj-art-1869098639f14d60a49bd2ddd84ccd222025-01-05T04:27:59ZengElsevierClinical Epidemiology and Global Health2213-39842025-01-0131101897New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort studyVenkatachalam Jayaseelan0Sitanshu Sekhar Kar1Mahadevan Duraiswamy2Manju Rajaram3Vikas Menon4Mukta Wyawahare5D.R. Veda Priya6Ravivarman Lakshmanasamy7Vanessa Ravel8Renjana Sivaji9Department of Preventive & Social Medicine, JIPMER, Puducherry, India; Corresponding author.Department of Preventive & Social Medicine, JIPMER, Puducherry, IndiaDepartment of Preventive & Social Medicine, JIPMER, Puducherry, IndiaDepartment of Pulmonary Medicine, JIPMER, Puducherry, IndiaDepartment of Psychiatry, JIPMER, Puducherry, IndiaDepartment of Medicine, JIPMER, Puducherry, IndiaDepartment of Community Medicine, Sri Venkateswara Medical College Hospital & Research Centre, Puducherry, IndiaWHO NCD, IndiaHealth Technology Assessment, JIPMER, Puducherry, IndiaDepartment of Preventive & Social Medicine, JIPMER, Puducherry, IndiaBackground: Diabetes Mellitus is one of the most common comorbidities in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, data on the incidence of Diabetes Mellitus among adults as post-COVID sequelae has been limited, and this study aims to determine the incidence and the associated factors of Diabetes Mellitus among adults who had COVID-19 infection. Methods: This prospective cohort study was carried out among COVID–19 symptomatic (moderate and severe) and asymptomatic cases admitted or reported in a tertiary care hospital in Puducherry, India. Participants were recruited between May and December 2022. It includes socio-demographic details and follow-up data on clinical symptoms and blood sugar levels for 724 participants without a prior history of Diabetes Mellitus, with 362 in the exposed group and 362 in the comparison group for incidence of Diabetes Mellitus, followed-up for 3 months. Results: Among the study participants, the relative risk of developing Diabetes Mellitus was 2.83 (95 % CI: 1.98–4.06) for the exposed group (moderate/severe cases) compared to the comparison group (mild/asymptomatic). Multivariable analysis further confirmed a relative risk of 2.01 (95 % CI: 1.26–3.20, p = 0.003) for moderate/severe COVID-19 cases, with significant associations for age, smoking, and comorbidities. Conclusion: By the 3rd month, new-onset Diabetes Mellitus was significantly higher in moderate to severe COVID-19 cases. Older age, smoking, and comorbidities were key factors. These findings highlight the need for closer monitoring of severe COVID-19 patients for new-onset diabetes in the post-COVID period.http://www.sciencedirect.com/science/article/pii/S2213398424003944Post-COVID sequelaeIncidence of diabetes MellitusNew onsetAssociationCohort study |
| spellingShingle | Venkatachalam Jayaseelan Sitanshu Sekhar Kar Mahadevan Duraiswamy Manju Rajaram Vikas Menon Mukta Wyawahare D.R. Veda Priya Ravivarman Lakshmanasamy Vanessa Ravel Renjana Sivaji New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study Clinical Epidemiology and Global Health Post-COVID sequelae Incidence of diabetes Mellitus New onset Association Cohort study |
| title | New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study |
| title_full | New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study |
| title_fullStr | New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study |
| title_full_unstemmed | New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study |
| title_short | New-onset Diabetes Mellitus among adults as sequelae of COVID-19 in selected tertiary care hospital, Puducherry – A cohort study |
| title_sort | new onset diabetes mellitus among adults as sequelae of covid 19 in selected tertiary care hospital puducherry a cohort study |
| topic | Post-COVID sequelae Incidence of diabetes Mellitus New onset Association Cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S2213398424003944 |
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