Methodological Study on Determination of Recombinant Adeno-Associated Virus Particle Titer Through Size Exclusion Chromatography with Multiangle Light Scattering and Collaborative Calibration of Standard Substances

Methodological Study on Determination of Recombinant Adeno-Associated Virus Particle Titer Through Size Exclusion Chromatography with Multiangle Light Scattering and Collaborative Calibration of Standard Substances

Adeno-associated virus (AAV) is a promising gene therapy vector due to its high transduction efficiency, low pathogenicity, low immunogenicity, and the ability to mediate the long-term stable expression of exogenous genes. The viral particle titer is an essential quality attribute of recombinant ade...

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Bibliographic Details
Main Authors: Dening Pei, Xiang Li, Hua Bi, Wenhong Fan, Heng Wang, Manli Cui, Xi Qin, Chenggang Liang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
adeno-associated virus
viral particle titer
multiangle light scattering
size exclusion chromatography
Online Access:https://www.mdpi.com/1420-3049/30/10/2170
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