Obesity and asthma during pregnancy: a systematic review and meta-analysis
Objective To assess the effect of obesity on the prevalence of asthma, obstetric outcomes and delivery outcomes in pregnant women with asthma. Methods A comprehensive systematic review and meta-analysis were conducted up to 31 March 2024, using four public search engines. Following the Preferred Rep...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2025-06-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/34/176/240259.full |
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| _version_ | 1849424732827418624 |
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| author | Hirotaka Matsuzaki Shinya Matsuzaki Yutaka Ueda Kensuke Fukuda Satoko Matsuzaki Kosuke Hiramatsu Tsuyoshi Hisa Aiko Okada Kazuya Mimura Hidenori Kage Michiko Kodama |
| author_facet | Hirotaka Matsuzaki Shinya Matsuzaki Yutaka Ueda Kensuke Fukuda Satoko Matsuzaki Kosuke Hiramatsu Tsuyoshi Hisa Aiko Okada Kazuya Mimura Hidenori Kage Michiko Kodama |
| author_sort | Hirotaka Matsuzaki |
| collection | DOAJ |
| description | Objective
To assess the effect of obesity on the prevalence of asthma, obstetric outcomes and delivery outcomes in pregnant women with asthma.
Methods
A comprehensive systematic review and meta-analysis were conducted up to 31 March 2024, using four public search engines. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, both quantitative and qualitative data were collected and analysed.
Results
We included 11 studies from 2006 to 2022 involving 77 611 386 pregnant patients (3.1% had asthma). Obesity increased the odds of asthma (n=2; OR 2.42, 95% CI 1.14–5.15) and increased that of uncontrolled asthma (n=6; OR 1.29, 95% CI 1.11–1.50) in pregnant women. In an adjusted pooled analysis, pregnant women with asthma were more likely to develop hypertensive disorders of pregnancy (HDP) (n=3; adjusted OR (aOR) 1.21, 95% CI 1.10–1.34), gestational diabetes mellitus (GDM) (n=3; aOR 1.14, 95% CI 1.04–1.26), fetal growth restriction (FGR) (n=2; aOR 1.18, 95% CI 1.15–1.21), preterm birth (PTB) (n=2; aOR 1.26, 95% CI 1.25–1.27), caesarean delivery (CD) (n=3; aOR 1.22, 95% CI 1.11–1.33) and severe maternal morbidity (n=1; aOR 1.50, 95% CI 1.45–1.55). Three comparator studies that examined the effect of obesity on obstetric outcomes cited obesity as a risk factor for HDP (n=1; aOR 1.7, 95% CI 1.3–2.3), GDM (n=1; aOR 4.2, 95% CI 2.8–6.3) and CD (n=1; aOR 1.6, 95% CI 1.3–2.0) in pregnant women with asthma.
Conclusions
Pregnancy with asthma may increase the risk of HDP, GDM, FGR, PTB and CD, and obesity has the potential to further increase the risk of HDP, GDM and CD in pregnant women with asthma. |
| format | Article |
| id | doaj-art-18663cb5b4b346d2ab6dc404e9c2e317 |
| institution | Kabale University |
| issn | 0905-9180 1600-0617 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj-art-18663cb5b4b346d2ab6dc404e9c2e3172025-08-20T03:30:03ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172025-06-013417610.1183/16000617.0259-20240259-2024Obesity and asthma during pregnancy: a systematic review and meta-analysisHirotaka Matsuzaki0Shinya Matsuzaki1Yutaka Ueda2Kensuke Fukuda3Satoko Matsuzaki4Kosuke Hiramatsu5Tsuyoshi Hisa6Aiko Okada7Kazuya Mimura8Hidenori Kage9Michiko Kodama10 Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Gynecology, Osaka International Cancer Institute, Osaka, Japan Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Obstetrics and Gynecology, Osaka General Medical Center, Osaka, Japan Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan Department of Gynecology, Osaka International Cancer Institute, Osaka, Japan Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan Objective To assess the effect of obesity on the prevalence of asthma, obstetric outcomes and delivery outcomes in pregnant women with asthma. Methods A comprehensive systematic review and meta-analysis were conducted up to 31 March 2024, using four public search engines. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, both quantitative and qualitative data were collected and analysed. Results We included 11 studies from 2006 to 2022 involving 77 611 386 pregnant patients (3.1% had asthma). Obesity increased the odds of asthma (n=2; OR 2.42, 95% CI 1.14–5.15) and increased that of uncontrolled asthma (n=6; OR 1.29, 95% CI 1.11–1.50) in pregnant women. In an adjusted pooled analysis, pregnant women with asthma were more likely to develop hypertensive disorders of pregnancy (HDP) (n=3; adjusted OR (aOR) 1.21, 95% CI 1.10–1.34), gestational diabetes mellitus (GDM) (n=3; aOR 1.14, 95% CI 1.04–1.26), fetal growth restriction (FGR) (n=2; aOR 1.18, 95% CI 1.15–1.21), preterm birth (PTB) (n=2; aOR 1.26, 95% CI 1.25–1.27), caesarean delivery (CD) (n=3; aOR 1.22, 95% CI 1.11–1.33) and severe maternal morbidity (n=1; aOR 1.50, 95% CI 1.45–1.55). Three comparator studies that examined the effect of obesity on obstetric outcomes cited obesity as a risk factor for HDP (n=1; aOR 1.7, 95% CI 1.3–2.3), GDM (n=1; aOR 4.2, 95% CI 2.8–6.3) and CD (n=1; aOR 1.6, 95% CI 1.3–2.0) in pregnant women with asthma. Conclusions Pregnancy with asthma may increase the risk of HDP, GDM, FGR, PTB and CD, and obesity has the potential to further increase the risk of HDP, GDM and CD in pregnant women with asthma.http://err.ersjournals.com/content/34/176/240259.full |
| spellingShingle | Hirotaka Matsuzaki Shinya Matsuzaki Yutaka Ueda Kensuke Fukuda Satoko Matsuzaki Kosuke Hiramatsu Tsuyoshi Hisa Aiko Okada Kazuya Mimura Hidenori Kage Michiko Kodama Obesity and asthma during pregnancy: a systematic review and meta-analysis European Respiratory Review |
| title | Obesity and asthma during pregnancy: a systematic review and meta-analysis |
| title_full | Obesity and asthma during pregnancy: a systematic review and meta-analysis |
| title_fullStr | Obesity and asthma during pregnancy: a systematic review and meta-analysis |
| title_full_unstemmed | Obesity and asthma during pregnancy: a systematic review and meta-analysis |
| title_short | Obesity and asthma during pregnancy: a systematic review and meta-analysis |
| title_sort | obesity and asthma during pregnancy a systematic review and meta analysis |
| url | http://err.ersjournals.com/content/34/176/240259.full |
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