An Exploration of Gene-Gene Interactions and Their Effects on Hypertension
Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that h...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2017/7208318 |
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| author | Ying Meng Susan Groth Jill R. Quinn John Bisognano Tong Tong Wu |
| author_facet | Ying Meng Susan Groth Jill R. Quinn John Bisognano Tong Tong Wu |
| author_sort | Ying Meng |
| collection | DOAJ |
| description | Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability. A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts. The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort. Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort. Four unique gene-gene interactions were found to be related to hypertension. Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies. Also, by including the identified gene-gene interactions, more variance was explained in hypertension. Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation. |
| format | Article |
| id | doaj-art-186334bd892045048acefee49b2c6139 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-186334bd892045048acefee49b2c61392025-02-03T05:53:46ZengWileyInternational Journal of Genomics2314-436X2314-43782017-01-01201710.1155/2017/72083187208318An Exploration of Gene-Gene Interactions and Their Effects on HypertensionYing Meng0Susan Groth1Jill R. Quinn2John Bisognano3Tong Tong Wu4School of Nursing, University of Rochester, Rochester, NY, USASchool of Nursing, University of Rochester, Rochester, NY, USASchool of Nursing, University of Rochester, Rochester, NY, USADepartment of Internal Medicine, Cardiology Division, University of Rochester Medical Center, Rochester, NY, USADepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USAHypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability. A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts. The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort. Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort. Four unique gene-gene interactions were found to be related to hypertension. Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies. Also, by including the identified gene-gene interactions, more variance was explained in hypertension. Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation.http://dx.doi.org/10.1155/2017/7208318 |
| spellingShingle | Ying Meng Susan Groth Jill R. Quinn John Bisognano Tong Tong Wu An Exploration of Gene-Gene Interactions and Their Effects on Hypertension International Journal of Genomics |
| title | An Exploration of Gene-Gene Interactions and Their Effects on Hypertension |
| title_full | An Exploration of Gene-Gene Interactions and Their Effects on Hypertension |
| title_fullStr | An Exploration of Gene-Gene Interactions and Their Effects on Hypertension |
| title_full_unstemmed | An Exploration of Gene-Gene Interactions and Their Effects on Hypertension |
| title_short | An Exploration of Gene-Gene Interactions and Their Effects on Hypertension |
| title_sort | exploration of gene gene interactions and their effects on hypertension |
| url | http://dx.doi.org/10.1155/2017/7208318 |
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