Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature
Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324010793 |
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| author | Hiba Ben Abdelhafidh Oumayma Ben Rejeb Nour Rouis Badra Bannour Neila Fathallah Imen Bannour |
| author_facet | Hiba Ben Abdelhafidh Oumayma Ben Rejeb Nour Rouis Badra Bannour Neila Fathallah Imen Bannour |
| author_sort | Hiba Ben Abdelhafidh |
| collection | DOAJ |
| description | Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently explored in the medical literature. Severe congenital malformations, although rare, have been reported, raising concerns about the impact of this drug on fetal development. We present a rare case of femoral agenesis observed in a woman who experienced a failed medical abortion with Misoprostol (Cytotec®), highlighting the need for a better understanding of the risks associated with fetal exposure to this drug and the implementation of rigorous follow-up measures after its use. |
| format | Article |
| id | doaj-art-186105d0644a4c5ebbcae957027bd35e |
| institution | OA Journals |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-186105d0644a4c5ebbcae957027bd35e2025-08-20T01:47:59ZengElsevierRadiology Case Reports1930-04332025-01-0120115816110.1016/j.radcr.2024.09.133Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literatureHiba Ben Abdelhafidh0Oumayma Ben Rejeb1Nour Rouis2Badra Bannour3Neila Fathallah4Imen Bannour5University of Sousse, Faculty of Medicine of Sousse, Obstetrics and Gynecology Department, University Hospital Farhat Hached of Sousse, TunisiaUniversity of Sousse, Faculty of Medicine of Sousse, Obstetrics and Gynecology Department, University Hospital Farhat Hached of Sousse, TunisiaUniversity of Sousse, Faculty of Medicine of Sousse, Obstetrics and Gynecology Department, University Hospital Farhat Hached of Sousse, TunisiaUniversity of Sousse, Faculty of Medicine of Sousse, Obstetrics and Gynecology Department, University Hospital Farhat Hached of Sousse, Tunisia; Corresponding author.University of Sousse, Department of Pharmacology, Faculty of Medicine of Sousse, TunisiaUniversity of Sousse, Faculty of Medicine of Sousse, Obstetrics and Gynecology Department, University Hospital Farhat Hached of Sousse, TunisiaMisoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently explored in the medical literature. Severe congenital malformations, although rare, have been reported, raising concerns about the impact of this drug on fetal development. We present a rare case of femoral agenesis observed in a woman who experienced a failed medical abortion with Misoprostol (Cytotec®), highlighting the need for a better understanding of the risks associated with fetal exposure to this drug and the implementation of rigorous follow-up measures after its use.http://www.sciencedirect.com/science/article/pii/S1930043324010793MisoprostolTeratogenicityFemoral agenesisFollow-up ultrasound |
| spellingShingle | Hiba Ben Abdelhafidh Oumayma Ben Rejeb Nour Rouis Badra Bannour Neila Fathallah Imen Bannour Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature Radiology Case Reports Misoprostol Teratogenicity Femoral agenesis Follow-up ultrasound |
| title | Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature |
| title_full | Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature |
| title_fullStr | Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature |
| title_full_unstemmed | Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature |
| title_short | Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature |
| title_sort | teratogenic effect of misoprostol following failure of elective abortion a case of femoral agenesis and review of the literature |
| topic | Misoprostol Teratogenicity Femoral agenesis Follow-up ultrasound |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324010793 |
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