Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD
Abstract Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep behaviour disorder (iRBD), a prodromal syn...
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Nature Portfolio
2025-04-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00942-z |
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| author | Ignacio Roura Jèssica Pardo Cristina Martín-Barceló Carles Falcon Javier Oltra Anna Campabadal Nuria Bargalló Mònica Serradell Gerard Mayà Angelica Montini Claustre Pont-Sunyer Carles Gaig Mariateresa Buongiorno Carme Junqué Alex Iranzo Bàrbara Segura |
| author_facet | Ignacio Roura Jèssica Pardo Cristina Martín-Barceló Carles Falcon Javier Oltra Anna Campabadal Nuria Bargalló Mònica Serradell Gerard Mayà Angelica Montini Claustre Pont-Sunyer Carles Gaig Mariateresa Buongiorno Carme Junqué Alex Iranzo Bàrbara Segura |
| author_sort | Ignacio Roura |
| collection | DOAJ |
| description | Abstract Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep behaviour disorder (iRBD), a prodromal synucleinopathy stage. Furthermore, its associations with clinical symptoms and brain structural abnormalities remain unexplored. We assessed the DTI-ALPS in sixty-two patients with iRBD and twenty-three healthy controls (HC), exploring its associations with clinical symptoms, cortical thickness and brain volumetric data. iRBD patients exhibited a lower DTI-ALPS and poorer odor identification, semantic fluency and processing speed relative to HC. The DTI-ALPS positively correlated with cognitive performance, olfactory function and amygdalar, hippocampal, brainstem and diencephalic volumes, and negatively with age in iRBD. Perivascular glymphatic activity is compromised in iRBD and is associated with brain atrophy and clinical risk factors of progression to alpha-synucleinopathies, supporting the potential of the DTI-ALPS index as an early imaging neurodegeneration marker. |
| format | Article |
| id | doaj-art-18603fc5d9d44f4e9e2b2ab51d0645ec |
| institution | OA Journals |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-18603fc5d9d44f4e9e2b2ab51d0645ec2025-08-20T02:19:07ZengNature Portfolionpj Parkinson's Disease2373-80572025-04-0111111010.1038/s41531-025-00942-zClinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBDIgnacio Roura0Jèssica Pardo1Cristina Martín-Barceló2Carles Falcon3Javier Oltra4Anna Campabadal5Nuria Bargalló6Mònica Serradell7Gerard Mayà8Angelica Montini9Claustre Pont-Sunyer10Carles Gaig11Mariateresa Buongiorno12Carme Junqué13Alex Iranzo14Bàrbara Segura15Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Sleep Unit, Neurology Service, Hospital Clínic Universitari de Barcelona, University of BarcelonaSleep Unit, Neurology Service, Hospital Clínic Universitari de Barcelona, University of BarcelonaSleep Unit, Neurology Service, Hospital Clínic Universitari de Barcelona, University of BarcelonaMovement Disorders Unit, Neurology Service, Fundació Privada Hospital Asil deInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Neurology Service, Hospital Universitari Vall d’HebronMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of BarcelonaAbstract Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep behaviour disorder (iRBD), a prodromal synucleinopathy stage. Furthermore, its associations with clinical symptoms and brain structural abnormalities remain unexplored. We assessed the DTI-ALPS in sixty-two patients with iRBD and twenty-three healthy controls (HC), exploring its associations with clinical symptoms, cortical thickness and brain volumetric data. iRBD patients exhibited a lower DTI-ALPS and poorer odor identification, semantic fluency and processing speed relative to HC. The DTI-ALPS positively correlated with cognitive performance, olfactory function and amygdalar, hippocampal, brainstem and diencephalic volumes, and negatively with age in iRBD. Perivascular glymphatic activity is compromised in iRBD and is associated with brain atrophy and clinical risk factors of progression to alpha-synucleinopathies, supporting the potential of the DTI-ALPS index as an early imaging neurodegeneration marker.https://doi.org/10.1038/s41531-025-00942-z |
| spellingShingle | Ignacio Roura Jèssica Pardo Cristina Martín-Barceló Carles Falcon Javier Oltra Anna Campabadal Nuria Bargalló Mònica Serradell Gerard Mayà Angelica Montini Claustre Pont-Sunyer Carles Gaig Mariateresa Buongiorno Carme Junqué Alex Iranzo Bàrbara Segura Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD npj Parkinson's Disease |
| title | Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD |
| title_full | Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD |
| title_fullStr | Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD |
| title_full_unstemmed | Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD |
| title_short | Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD |
| title_sort | clinical and brain volumetric correlates of decreased dti alps suggestive of local glymphatic dysfunction in irbd |
| url | https://doi.org/10.1038/s41531-025-00942-z |
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