Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies
Intrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI), a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to delivery, the doubly...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/53921 |
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| author | Nicoletta Iacovidou Maria Boutsikou Demetrios Gourgiotis Despina D. Briana Stavroula Baka Venetia-Maria Vraila Louiza Kontara Demetrios Hassiakos Ariadne Malamitsi-Puchner |
| author_facet | Nicoletta Iacovidou Maria Boutsikou Demetrios Gourgiotis Despina D. Briana Stavroula Baka Venetia-Maria Vraila Louiza Kontara Demetrios Hassiakos Ariadne Malamitsi-Puchner |
| author_sort | Nicoletta Iacovidou |
| collection | DOAJ |
| description | Intrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow
redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI),
a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to
delivery, the doubly clamped umbilical cords (representing fetal state), and their 20 IUGR
and 20 appropriate-for-gestational-age (AGA) neonates on day 1 and 4 postpartum. At all
time points, no differences in cTnI levels were observed between the AGA and IUGR groups.
Strong positive correlations were documented between maternal and fetal/neonatal values
(r≥.498, P≤.025 in all cases in the AGA and r≥.615, P≤.009 in all cases in the IUGR group). These results may indicate (a) normal
heart function, due to heart sparing, in the IUGR group (b) potential crossing of the placental
barrier by cTnI in both groups |
| format | Article |
| id | doaj-art-185ac4d1f9ae49e28914a4ea956190a3 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-185ac4d1f9ae49e28914a4ea956190a32025-08-20T02:02:15ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/5392153921Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted PregnanciesNicoletta Iacovidou0Maria Boutsikou1Demetrios Gourgiotis2Despina D. Briana3Stavroula Baka4Venetia-Maria Vraila5Louiza Kontara6Demetrios Hassiakos7Ariadne Malamitsi-Puchner8Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceNeonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceResearch Laboratories, 2nd Department of Paediatrics, Athens University Medical School, Athens 10682, GreeceNeonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceNeonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceResearch Laboratories, 2nd Department of Paediatrics, Athens University Medical School, Athens 10682, GreeceNeonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceNeonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceNeonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, GreeceIntrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI), a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to delivery, the doubly clamped umbilical cords (representing fetal state), and their 20 IUGR and 20 appropriate-for-gestational-age (AGA) neonates on day 1 and 4 postpartum. At all time points, no differences in cTnI levels were observed between the AGA and IUGR groups. Strong positive correlations were documented between maternal and fetal/neonatal values (r≥.498, P≤.025 in all cases in the AGA and r≥.615, P≤.009 in all cases in the IUGR group). These results may indicate (a) normal heart function, due to heart sparing, in the IUGR group (b) potential crossing of the placental barrier by cTnI in both groupshttp://dx.doi.org/10.1155/2007/53921 |
| spellingShingle | Nicoletta Iacovidou Maria Boutsikou Demetrios Gourgiotis Despina D. Briana Stavroula Baka Venetia-Maria Vraila Louiza Kontara Demetrios Hassiakos Ariadne Malamitsi-Puchner Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies Mediators of Inflammation |
| title | Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies |
| title_full | Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies |
| title_fullStr | Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies |
| title_full_unstemmed | Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies |
| title_short | Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies |
| title_sort | perinatal changes of cardiac troponin i in normal and intrauterine growth restricted pregnancies |
| url | http://dx.doi.org/10.1155/2007/53921 |
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