Study of the metabolome features of patients with COVID-19
Aim. To analyze the metabolomic profile of patients with coronavirus disease 2019 (COVID-19) using mass spectrometry methods and taking into account clinical and laboratory history. Studying the relationship between the severity of COVID-19 symptoms and the concentration of primary metabolites, prim...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2023-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3711 |
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| author | Y. V. Russkikh N. N. Sushentseva O. S. Popov S. V. Apalko A. Yu. Anisenkova S. V. Mosenko A. M. Sarana S. G. Shcherbak |
| author_facet | Y. V. Russkikh N. N. Sushentseva O. S. Popov S. V. Apalko A. Yu. Anisenkova S. V. Mosenko A. M. Sarana S. G. Shcherbak |
| author_sort | Y. V. Russkikh |
| collection | DOAJ |
| description | Aim. To analyze the metabolomic profile of patients with coronavirus disease 2019 (COVID-19) using mass spectrometry methods and taking into account clinical and laboratory history. Studying the relationship between the severity of COVID-19 symptoms and the concentration of primary metabolites, primarily amino acids.Material and methods. The retrospective study included serum samples from a total of 935 people (445 men and 490 women) with COVID-19 from the collection of the biobank of the City Hospital № 40. A metabolomic profile was studied in all samples using chromatography-mass spectrometry. The R language was used for statistical data processing.Results. Based on the analysis, a difference in the metabolic profile of patients with COVID-19 was identified depending on the disease severity — for 52 of the 84 detected compounds, differences were observed with a significance of p<0,01. Significant differences in concentration were recorded for organic acids, amino acids and their derivatives.Conclusion. Using samples from the biobank collection, a metabolomic study of the biomaterial of patients hospitalized with a diagnosis of COVID-19 was carried out. According to the results obtained, kynurenine, phenylalanine and acetylcarnitine are associated with COVID-19 severity. Differences in the metabolomic profile were identified in patients with cytokine storm at the time of blood collection. Potential biomarkers for cytokine storm were identified. |
| format | Article |
| id | doaj-art-18557ac1a99c4e87a2e6225ee53618b1 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-18557ac1a99c4e87a2e6225ee53618b12025-08-20T03:18:35Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252023-12-01221110.15829/1728-8800-2023-37112796Study of the metabolome features of patients with COVID-19Y. V. Russkikh0N. N. Sushentseva1O. S. Popov2S. V. Apalko3A. Yu. Anisenkova4S. V. Mosenko5A. M. Sarana6S. G. Shcherbak7City Hospital № 40 of the Kurortny DistrictCity Hospital № 40 of the Kurortny DistrictCity Hospital № 40 of the Kurortny District; Saint Petersburg State UniversityCity Hospital № 40 of the Kurortny District; Saint Petersburg State UniversityCity Hospital № 40 of the Kurortny District; Saint Petersburg State UniversityCity Hospital № 40 of the Kurortny District; Saint Petersburg State UniversitySaintPetersburg State University; Health Committee of SaintPetersburgCity Hospital № 40 of the Kurortny District; Saint Petersburg State UniversityAim. To analyze the metabolomic profile of patients with coronavirus disease 2019 (COVID-19) using mass spectrometry methods and taking into account clinical and laboratory history. Studying the relationship between the severity of COVID-19 symptoms and the concentration of primary metabolites, primarily amino acids.Material and methods. The retrospective study included serum samples from a total of 935 people (445 men and 490 women) with COVID-19 from the collection of the biobank of the City Hospital № 40. A metabolomic profile was studied in all samples using chromatography-mass spectrometry. The R language was used for statistical data processing.Results. Based on the analysis, a difference in the metabolic profile of patients with COVID-19 was identified depending on the disease severity — for 52 of the 84 detected compounds, differences were observed with a significance of p<0,01. Significant differences in concentration were recorded for organic acids, amino acids and their derivatives.Conclusion. Using samples from the biobank collection, a metabolomic study of the biomaterial of patients hospitalized with a diagnosis of COVID-19 was carried out. According to the results obtained, kynurenine, phenylalanine and acetylcarnitine are associated with COVID-19 severity. Differences in the metabolomic profile were identified in patients with cytokine storm at the time of blood collection. Potential biomarkers for cytokine storm were identified.https://cardiovascular.elpub.ru/jour/article/view/3711biobankcovid-19metabolomic profilegas chromatography-mass spectrometry analysiscytokine storm |
| spellingShingle | Y. V. Russkikh N. N. Sushentseva O. S. Popov S. V. Apalko A. Yu. Anisenkova S. V. Mosenko A. M. Sarana S. G. Shcherbak Study of the metabolome features of patients with COVID-19 Кардиоваскулярная терапия и профилактика biobank covid-19 metabolomic profile gas chromatography-mass spectrometry analysis cytokine storm |
| title | Study of the metabolome features of patients with COVID-19 |
| title_full | Study of the metabolome features of patients with COVID-19 |
| title_fullStr | Study of the metabolome features of patients with COVID-19 |
| title_full_unstemmed | Study of the metabolome features of patients with COVID-19 |
| title_short | Study of the metabolome features of patients with COVID-19 |
| title_sort | study of the metabolome features of patients with covid 19 |
| topic | biobank covid-19 metabolomic profile gas chromatography-mass spectrometry analysis cytokine storm |
| url | https://cardiovascular.elpub.ru/jour/article/view/3711 |
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