Nanoparticle approaches for manipulating cytokine delivery and neutralization
Cytokines are crucial regulators of inflammation and immune tolerance, making them promising targets for treating immune-related diseases like cancer, infections, and autoimmune disorders. While cytokine-based therapies have shown potential, challenges such as dose-limiting toxicity and suboptimal p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592795/full |
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| _version_ | 1850214748347432960 |
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| author | Rui Wang Luke J. Kubiatowicz Runhe Zhang Lin Bao Ronnie H. Fang Ronnie H. Fang Liangfang Zhang |
| author_facet | Rui Wang Luke J. Kubiatowicz Runhe Zhang Lin Bao Ronnie H. Fang Ronnie H. Fang Liangfang Zhang |
| author_sort | Rui Wang |
| collection | DOAJ |
| description | Cytokines are crucial regulators of inflammation and immune tolerance, making them promising targets for treating immune-related diseases like cancer, infections, and autoimmune disorders. While cytokine-based therapies have shown potential, challenges such as dose-limiting toxicity and suboptimal pharmacokinetics have constrained their clinical success. Recent advancements in nanotechnology offer innovative solutions to these limitations, particularly through the use of nanoparticle-based platforms that enhance cytokine delivery and neutralization. This review begins by examining the landscape of cytokine delivery, emphasizing how it can be accomplished using nanoparticle systems encapsulating proteins, DNA or mRNA payloads. We then discuss recent progress on platforms for nanoparticle-based cytokine neutralization, including nanoparticle–antibody complexes and cell membrane-coated nanoparticles. Finally, we highlight the latest clinical developments in cytokine-based therapies employing these strategies before addressing the critical challenges ahead that need to be overcome in order to fully realize the therapeutic potential of nanoparticle-based cytokine manipulation. |
| format | Article |
| id | doaj-art-184fce8430264db8b3f11dd2ee085989 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-184fce8430264db8b3f11dd2ee0859892025-08-20T02:08:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15927951592795Nanoparticle approaches for manipulating cytokine delivery and neutralizationRui Wang0Luke J. Kubiatowicz1Runhe Zhang2Lin Bao3Ronnie H. Fang4Ronnie H. Fang5Liangfang Zhang6Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, San Diego, United StatesAiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, San Diego, United StatesAiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, San Diego, United StatesAiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, San Diego, United StatesAiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, San Diego, United StatesDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, San Diego, United StatesAiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, San Diego, United StatesCytokines are crucial regulators of inflammation and immune tolerance, making them promising targets for treating immune-related diseases like cancer, infections, and autoimmune disorders. While cytokine-based therapies have shown potential, challenges such as dose-limiting toxicity and suboptimal pharmacokinetics have constrained their clinical success. Recent advancements in nanotechnology offer innovative solutions to these limitations, particularly through the use of nanoparticle-based platforms that enhance cytokine delivery and neutralization. This review begins by examining the landscape of cytokine delivery, emphasizing how it can be accomplished using nanoparticle systems encapsulating proteins, DNA or mRNA payloads. We then discuss recent progress on platforms for nanoparticle-based cytokine neutralization, including nanoparticle–antibody complexes and cell membrane-coated nanoparticles. Finally, we highlight the latest clinical developments in cytokine-based therapies employing these strategies before addressing the critical challenges ahead that need to be overcome in order to fully realize the therapeutic potential of nanoparticle-based cytokine manipulation.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592795/fullcytokine deliverycytokine neutralizationnanodeliverybiodetoxificationbiomimetic nanoparticleautoimmune disease |
| spellingShingle | Rui Wang Luke J. Kubiatowicz Runhe Zhang Lin Bao Ronnie H. Fang Ronnie H. Fang Liangfang Zhang Nanoparticle approaches for manipulating cytokine delivery and neutralization Frontiers in Immunology cytokine delivery cytokine neutralization nanodelivery biodetoxification biomimetic nanoparticle autoimmune disease |
| title | Nanoparticle approaches for manipulating cytokine delivery and neutralization |
| title_full | Nanoparticle approaches for manipulating cytokine delivery and neutralization |
| title_fullStr | Nanoparticle approaches for manipulating cytokine delivery and neutralization |
| title_full_unstemmed | Nanoparticle approaches for manipulating cytokine delivery and neutralization |
| title_short | Nanoparticle approaches for manipulating cytokine delivery and neutralization |
| title_sort | nanoparticle approaches for manipulating cytokine delivery and neutralization |
| topic | cytokine delivery cytokine neutralization nanodelivery biodetoxification biomimetic nanoparticle autoimmune disease |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592795/full |
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