Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo
Abstract Pathogens have been documented to be transmissible between humans and non‐human primates (NHPs), with NHPs demonstrating susceptibility to human viruses. Conducting surveillance for viruses in NHPs to identify potential zoonotic agents that may emerge or pose a high risk of spillover remain...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Animal Research and One Health |
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| Online Access: | https://doi.org/10.1002/aro2.79 |
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| _version_ | 1850128981066514432 |
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| author | Ruiying Liang Xinming Tang Lin Liang Jiabo Ding Ye Tian Yixian Qin Sufen Zhao Lixia Zhang Tianchun Pu Xuefeng Liu Jinpeng Liu Chenglin Zhang Zibin Li Ting Jia |
| author_facet | Ruiying Liang Xinming Tang Lin Liang Jiabo Ding Ye Tian Yixian Qin Sufen Zhao Lixia Zhang Tianchun Pu Xuefeng Liu Jinpeng Liu Chenglin Zhang Zibin Li Ting Jia |
| author_sort | Ruiying Liang |
| collection | DOAJ |
| description | Abstract Pathogens have been documented to be transmissible between humans and non‐human primates (NHPs), with NHPs demonstrating susceptibility to human viruses. Conducting surveillance for viruses in NHPs to identify potential zoonotic agents that may emerge or pose a high risk of spillover remains a critical strategy for preparing for and responding to future zoonotic events. This study employed viral metagenomic analysis on nine randomly selected NHPs from the Zoo in China to detect potential pathogens within captive environments. The analysis identified the presence of picornavirus Encephalomyocarditis virus (EMCV), poxvirus (BeAn 58,058 virus, BAV), and retroviruses (human endogenous retrovirus, HERV and baboon endogenous virus, BaEV). These viruses exhibited significant genetic homology to established viral strains, with EMCV demonstrating close relatedness to a strain previously detected in the United States, and BAV beling newly identified in NHPs. The study suggests that zoo rodents, particularly rats, serve as the primary reservoirs for the viruses, thereby posing a potential threat to public health. Therefore, this underscores the imperative to enhance rodent control measures within zoological institutions and provides strategic recommendations for mitigating interspecies viral transmission. |
| format | Article |
| id | doaj-art-1846bd0133d24fa49ffc8b8382a03fe0 |
| institution | OA Journals |
| issn | 2835-5075 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Research and One Health |
| spelling | doaj-art-1846bd0133d24fa49ffc8b8382a03fe02025-08-20T02:33:08ZengWileyAnimal Research and One Health2835-50752025-05-013221722810.1002/aro2.79Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zooRuiying Liang0Xinming Tang1Lin Liang2Jiabo Ding3Ye Tian4Yixian Qin5Sufen Zhao6Lixia Zhang7Tianchun Pu8Xuefeng Liu9Jinpeng Liu10Chenglin Zhang11Zibin Li12Ting Jia13Key Laboratory of Animal Biosafety Risk Prevention and Control (North) & Key Laboratory of Veterinary Biological Products and Chemical Drugs of MARA Institute of Animal Sciences, Chinese Academy of Agricultural Science Beijing ChinaKey Laboratory of Animal Biosafety Risk Prevention and Control (North) & Key Laboratory of Veterinary Biological Products and Chemical Drugs of MARA Institute of Animal Sciences, Chinese Academy of Agricultural Science Beijing ChinaKey Laboratory of Animal Biosafety Risk Prevention and Control (North) & Key Laboratory of Veterinary Biological Products and Chemical Drugs of MARA Institute of Animal Sciences, Chinese Academy of Agricultural Science Beijing ChinaKey Laboratory of Animal Biosafety Risk Prevention and Control (North) & Key Laboratory of Veterinary Biological Products and Chemical Drugs of MARA Institute of Animal Sciences, Chinese Academy of Agricultural Science Beijing ChinaChina Institute of Veterinary Drug Control Beijing ChinaChina Institute of Veterinary Drug Control Beijing ChinaBeijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo Beijing ChinaTaiyuan Zoo Taiyuan City Shanxi Province ChinaBeijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo Beijing ChinaBeijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo Beijing ChinaBeijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo Beijing ChinaBeijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo Beijing ChinaDepartment of Bioengineering College of Life and Health Dalian University Dalian Liaoning ChinaBeijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo Beijing ChinaAbstract Pathogens have been documented to be transmissible between humans and non‐human primates (NHPs), with NHPs demonstrating susceptibility to human viruses. Conducting surveillance for viruses in NHPs to identify potential zoonotic agents that may emerge or pose a high risk of spillover remains a critical strategy for preparing for and responding to future zoonotic events. This study employed viral metagenomic analysis on nine randomly selected NHPs from the Zoo in China to detect potential pathogens within captive environments. The analysis identified the presence of picornavirus Encephalomyocarditis virus (EMCV), poxvirus (BeAn 58,058 virus, BAV), and retroviruses (human endogenous retrovirus, HERV and baboon endogenous virus, BaEV). These viruses exhibited significant genetic homology to established viral strains, with EMCV demonstrating close relatedness to a strain previously detected in the United States, and BAV beling newly identified in NHPs. The study suggests that zoo rodents, particularly rats, serve as the primary reservoirs for the viruses, thereby posing a potential threat to public health. Therefore, this underscores the imperative to enhance rodent control measures within zoological institutions and provides strategic recommendations for mitigating interspecies viral transmission.https://doi.org/10.1002/aro2.79non‐human primatespicornaviruspoxvirusretrovirusviral metagenomics |
| spellingShingle | Ruiying Liang Xinming Tang Lin Liang Jiabo Ding Ye Tian Yixian Qin Sufen Zhao Lixia Zhang Tianchun Pu Xuefeng Liu Jinpeng Liu Chenglin Zhang Zibin Li Ting Jia Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo Animal Research and One Health non‐human primates picornavirus poxvirus retrovirus viral metagenomics |
| title | Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo |
| title_full | Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo |
| title_fullStr | Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo |
| title_full_unstemmed | Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo |
| title_short | Viral metagenomic analysis reveals potential biological hazards in non‐human primates in a zoo |
| title_sort | viral metagenomic analysis reveals potential biological hazards in non human primates in a zoo |
| topic | non‐human primates picornavirus poxvirus retrovirus viral metagenomics |
| url | https://doi.org/10.1002/aro2.79 |
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