Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report
Limbic encephalitis (LE) associated with anti-LGI1 antibodies is an autoimmune disorder characterized by memory decline, behavioral changes, and temporal lobe epilepsy. Faciobrachial dystonic seizures (FBDS) are a hallmark symptom, often preceding cognitive and psychiatric issues. This report presen...
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MDPI AG
2025-05-01
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| Series: | NeuroSci |
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| Online Access: | https://www.mdpi.com/2673-4087/6/2/43 |
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| author | Francesco Rossato Andrea Porsio Diego Cecchin Matteo Atzori Anna Maria Basile Marco Zoccarato |
| author_facet | Francesco Rossato Andrea Porsio Diego Cecchin Matteo Atzori Anna Maria Basile Marco Zoccarato |
| author_sort | Francesco Rossato |
| collection | DOAJ |
| description | Limbic encephalitis (LE) associated with anti-LGI1 antibodies is an autoimmune disorder characterized by memory decline, behavioral changes, and temporal lobe epilepsy. Faciobrachial dystonic seizures (FBDS) are a hallmark symptom, often preceding cognitive and psychiatric issues. This report presents an 80-year-old male with LGI1 encephalitis, initially manifesting as FBDS. A lung adenocarcinoma was diagnosed two months after the onset of neurological symptoms. Clinical and paraclinical data, including MRI and [18]FDG PET imaging, are described. The patient responded to immunotherapy, including steroids and plasma exchange, along with tumor resection. Following treatment, neurological symptoms resolved, except for mild anxiety and apathy. Further research is needed to determine whether LGI1 encephalitis may occasionally have a paraneoplastic origin, potentially influencing screening and management strategies. |
| format | Article |
| id | doaj-art-183fa85e2a6c47ccbd48b472704f23be |
| institution | OA Journals |
| issn | 2673-4087 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | NeuroSci |
| spelling | doaj-art-183fa85e2a6c47ccbd48b472704f23be2025-08-20T02:21:46ZengMDPI AGNeuroSci2673-40872025-05-01624310.3390/neurosci6020043Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case ReportFrancesco Rossato0Andrea Porsio1Diego Cecchin2Matteo Atzori3Anna Maria Basile4Marco Zoccarato5Neurology Unit, Ospedale Sant’Antonio, Azienda Ospedale Università di Padova, 35218 Padua, ItalyNeurology Unit, Ospedale Sant’Antonio, Azienda Ospedale Università di Padova, 35218 Padua, ItalyNuclear Medicine Unit, Department of Medicine—DIMED, Azienda Ospedale Università di Padova, 35128 Padua, ItalyNeurology Unit, Ospedale Sant’Antonio, Azienda Ospedale Università di Padova, 35218 Padua, ItalyNeurology Unit, Ospedale Sant’Antonio, Azienda Ospedale Università di Padova, 35218 Padua, ItalyNeurology Unit, Ospedale Sant’Antonio, Azienda Ospedale Università di Padova, 35218 Padua, ItalyLimbic encephalitis (LE) associated with anti-LGI1 antibodies is an autoimmune disorder characterized by memory decline, behavioral changes, and temporal lobe epilepsy. Faciobrachial dystonic seizures (FBDS) are a hallmark symptom, often preceding cognitive and psychiatric issues. This report presents an 80-year-old male with LGI1 encephalitis, initially manifesting as FBDS. A lung adenocarcinoma was diagnosed two months after the onset of neurological symptoms. Clinical and paraclinical data, including MRI and [18]FDG PET imaging, are described. The patient responded to immunotherapy, including steroids and plasma exchange, along with tumor resection. Following treatment, neurological symptoms resolved, except for mild anxiety and apathy. Further research is needed to determine whether LGI1 encephalitis may occasionally have a paraneoplastic origin, potentially influencing screening and management strategies.https://www.mdpi.com/2673-4087/6/2/43LGI1 antibodieslimbic encephalitisparaneoplastic neurological syndromeslung canceradenocarcinoma |
| spellingShingle | Francesco Rossato Andrea Porsio Diego Cecchin Matteo Atzori Anna Maria Basile Marco Zoccarato Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report NeuroSci LGI1 antibodies limbic encephalitis paraneoplastic neurological syndromes lung cancer adenocarcinoma |
| title | Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report |
| title_full | Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report |
| title_fullStr | Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report |
| title_full_unstemmed | Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report |
| title_short | Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report |
| title_sort | paraneoplastic lgi1 encephalitis associated with lung adenocarcinoma a case report |
| topic | LGI1 antibodies limbic encephalitis paraneoplastic neurological syndromes lung cancer adenocarcinoma |
| url | https://www.mdpi.com/2673-4087/6/2/43 |
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