Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment
In well-selected patients who choose to pursue breast conservation therapy (BCT) for early-stage breast cancer, partial breast irradiation (PBI) delivered externally or intraoperatively, may be a viable alternative to conventional whole breast irradiation. Two large, contemporary randomized trials h...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/214325 |
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| _version_ | 1849309243117666304 |
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| author | Harriet B. Eldredge-Hindy Anne L. Rosenberg Nicole L. Simone |
| author_facet | Harriet B. Eldredge-Hindy Anne L. Rosenberg Nicole L. Simone |
| author_sort | Harriet B. Eldredge-Hindy |
| collection | DOAJ |
| description | In well-selected patients who choose to pursue breast conservation therapy (BCT) for early-stage breast cancer, partial breast irradiation (PBI) delivered externally or intraoperatively, may be a viable alternative to conventional whole breast irradiation. Two large, contemporary randomized trials have demonstrated breast intraoperative radiotherapy (IORT) to be noninferior to whole breast external beam radiotherapy (EBRT) when assessing for ipsilateral breast tumor recurrence in select patients. Additionally, IORT and other PBI techniques are likely to be more widely adopted in the future because they improve patient convenience by offering an accelerated course of treatment. Coupled with these novel techniques for breast radiotherapy (RT) are distinct toxicity profiles and unique cosmetic alterations that differ from conventional breast EBRT and have the potential to impact disease surveillance and patient satisfaction. This paper will review the level-one evidence for treatment efficacy as well as important secondary endpoints like RT toxicity, breast cosmesis, quality of life, patient satisfaction, and surveillance mammography following BCT with IORT. |
| format | Article |
| id | doaj-art-183b5b1f034e4f5da45f4bc3f80eb62b |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-183b5b1f034e4f5da45f4bc3f80eb62b2025-08-20T03:54:12ZengWileyInternational Journal of Breast Cancer2090-31702090-31892014-01-01201410.1155/2014/214325214325Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting TreatmentHarriet B. Eldredge-Hindy0Anne L. Rosenberg1Nicole L. Simone2Department of Radiation Oncology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, 111 South 11th Street, Philadelphia, PA 19107, USADepartment of Surgery, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, 111 South 11th Street, Philadelphia, PA 19107, USAIn well-selected patients who choose to pursue breast conservation therapy (BCT) for early-stage breast cancer, partial breast irradiation (PBI) delivered externally or intraoperatively, may be a viable alternative to conventional whole breast irradiation. Two large, contemporary randomized trials have demonstrated breast intraoperative radiotherapy (IORT) to be noninferior to whole breast external beam radiotherapy (EBRT) when assessing for ipsilateral breast tumor recurrence in select patients. Additionally, IORT and other PBI techniques are likely to be more widely adopted in the future because they improve patient convenience by offering an accelerated course of treatment. Coupled with these novel techniques for breast radiotherapy (RT) are distinct toxicity profiles and unique cosmetic alterations that differ from conventional breast EBRT and have the potential to impact disease surveillance and patient satisfaction. This paper will review the level-one evidence for treatment efficacy as well as important secondary endpoints like RT toxicity, breast cosmesis, quality of life, patient satisfaction, and surveillance mammography following BCT with IORT.http://dx.doi.org/10.1155/2014/214325 |
| spellingShingle | Harriet B. Eldredge-Hindy Anne L. Rosenberg Nicole L. Simone Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment International Journal of Breast Cancer |
| title | Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment |
| title_full | Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment |
| title_fullStr | Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment |
| title_full_unstemmed | Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment |
| title_short | Intraoperative Radiotherapy for Breast Cancer: The Lasting Effects of a Fleeting Treatment |
| title_sort | intraoperative radiotherapy for breast cancer the lasting effects of a fleeting treatment |
| url | http://dx.doi.org/10.1155/2014/214325 |
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