Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based Compounds
Magnetic microrobots have the potential for anti‐cancer drug delivery; however, using dual‐drug to counter drug resistance, a critical issue in cancer research, has only been briefly investigated. This study introduces the double‐layered metal‐organic‐frameworks (MOFs)‐based microswimmers for sustai...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
|
| Series: | Advanced Intelligent Systems |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/aisy.202400244 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850243587549167616 |
|---|---|
| author | Yukun Zhong Haining Li Teng Jiang Xueliang Mu Munetoshi Seki U Kei Cheang |
| author_facet | Yukun Zhong Haining Li Teng Jiang Xueliang Mu Munetoshi Seki U Kei Cheang |
| author_sort | Yukun Zhong |
| collection | DOAJ |
| description | Magnetic microrobots have the potential for anti‐cancer drug delivery; however, using dual‐drug to counter drug resistance, a critical issue in cancer research, has only been briefly investigated. This study introduces the double‐layered metal‐organic‐frameworks (MOFs)‐based microswimmers for sustained dual‐drug delivery. These microswimmers are made up of ZIF‐8 and MIL‐100, biocompatible MOFs, that can selectively adsorb two types of drugs. The MOFs increase the surface area of the microswimmers by ≈2.42 times, which greatly enhances drug adsorption, and improves hydrophilicity, which reduces adhesion for surface locomotion. Their biocompatibility and dual‐drug adsorption are verified through cell viability and drug‐loading tests. The microswimmers have remarkable versatility in loading different drug combinations (DHA + 5‐FU, CPT‐11, or DOX), indicating the potential for adaptive therapy. They can inhibit cancer cells for up to 72 h through the sustained release of dual drugs. In contrast, drug treatments without microswimmers only inhibit cell proliferation for 24 h, leading to a significant rebound. This study provides a method to mass fabricate fully biocompatible microrobots with dual drug loading versatility and high drug adsorption capacity; thus, suggests a powerful platform for sustained adaptive dual‐drug therapy. |
| format | Article |
| id | doaj-art-18304ca0540d44fa97172e619084efb4 |
| institution | OA Journals |
| issn | 2640-4567 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Intelligent Systems |
| spelling | doaj-art-18304ca0540d44fa97172e619084efb42025-08-20T01:59:57ZengWileyAdvanced Intelligent Systems2640-45672024-12-01612n/an/a10.1002/aisy.202400244Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based CompoundsYukun Zhong0Haining Li1Teng Jiang2Xueliang Mu3Munetoshi Seki4U Kei Cheang5Department of Mechanical and Energy Engineering Southern University of Science and Technology Shenzhen 518055 ChinaDepartment of Electrical Engineering and Information Systems Graduate School of Engineering The University of Tokyo Tokyo 113‐8656 JapanDepartment of Mechanical and Energy Engineering Southern University of Science and Technology Shenzhen 518055 ChinaDepartment of Mechanical and Manufacturing Engineering University of Calgary Calgary Alberta T2N 1N4 CanadaDepartment of Electrical Engineering and Information Systems Graduate School of Engineering The University of Tokyo Tokyo 113‐8656 JapanDepartment of Mechanical and Energy Engineering Southern University of Science and Technology Shenzhen 518055 ChinaMagnetic microrobots have the potential for anti‐cancer drug delivery; however, using dual‐drug to counter drug resistance, a critical issue in cancer research, has only been briefly investigated. This study introduces the double‐layered metal‐organic‐frameworks (MOFs)‐based microswimmers for sustained dual‐drug delivery. These microswimmers are made up of ZIF‐8 and MIL‐100, biocompatible MOFs, that can selectively adsorb two types of drugs. The MOFs increase the surface area of the microswimmers by ≈2.42 times, which greatly enhances drug adsorption, and improves hydrophilicity, which reduces adhesion for surface locomotion. Their biocompatibility and dual‐drug adsorption are verified through cell viability and drug‐loading tests. The microswimmers have remarkable versatility in loading different drug combinations (DHA + 5‐FU, CPT‐11, or DOX), indicating the potential for adaptive therapy. They can inhibit cancer cells for up to 72 h through the sustained release of dual drugs. In contrast, drug treatments without microswimmers only inhibit cell proliferation for 24 h, leading to a significant rebound. This study provides a method to mass fabricate fully biocompatible microrobots with dual drug loading versatility and high drug adsorption capacity; thus, suggests a powerful platform for sustained adaptive dual‐drug therapy.https://doi.org/10.1002/aisy.202400244dual‐drugmagnetic controlmetal‐organic‐frameworksmicrorobotmicroswimmer |
| spellingShingle | Yukun Zhong Haining Li Teng Jiang Xueliang Mu Munetoshi Seki U Kei Cheang Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based Compounds Advanced Intelligent Systems dual‐drug magnetic control metal‐organic‐frameworks microrobot microswimmer |
| title | Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based Compounds |
| title_full | Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based Compounds |
| title_fullStr | Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based Compounds |
| title_full_unstemmed | Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based Compounds |
| title_short | Double‐Layered Metal‐Organic‐Frameworks‐Based Microswimmers for Adaptive Dual‐Drug Anti‐Cancer Therapy Using Artemisinin‐Based Compounds |
| title_sort | double layered metal organic frameworks based microswimmers for adaptive dual drug anti cancer therapy using artemisinin based compounds |
| topic | dual‐drug magnetic control metal‐organic‐frameworks microrobot microswimmer |
| url | https://doi.org/10.1002/aisy.202400244 |
| work_keys_str_mv | AT yukunzhong doublelayeredmetalorganicframeworksbasedmicroswimmersforadaptivedualdruganticancertherapyusingartemisininbasedcompounds AT hainingli doublelayeredmetalorganicframeworksbasedmicroswimmersforadaptivedualdruganticancertherapyusingartemisininbasedcompounds AT tengjiang doublelayeredmetalorganicframeworksbasedmicroswimmersforadaptivedualdruganticancertherapyusingartemisininbasedcompounds AT xueliangmu doublelayeredmetalorganicframeworksbasedmicroswimmersforadaptivedualdruganticancertherapyusingartemisininbasedcompounds AT munetoshiseki doublelayeredmetalorganicframeworksbasedmicroswimmersforadaptivedualdruganticancertherapyusingartemisininbasedcompounds AT ukeicheang doublelayeredmetalorganicframeworksbasedmicroswimmersforadaptivedualdruganticancertherapyusingartemisininbasedcompounds |