IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8214656 |
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| author | Josephine Diony Nanda Tzong-Shiann Ho Rahmat Dani Satria Ming-Kai Jhan Yung-Ting Wang Chiou-Feng Lin |
| author_facet | Josephine Diony Nanda Tzong-Shiann Ho Rahmat Dani Satria Ming-Kai Jhan Yung-Ting Wang Chiou-Feng Lin |
| author_sort | Josephine Diony Nanda |
| collection | DOAJ |
| description | Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies. |
| format | Article |
| id | doaj-art-18302b0ad20a4d998e7b8283cfa41b20 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-18302b0ad20a4d998e7b8283cfa41b202025-08-20T03:54:12ZengWileyJournal of Immunology Research2314-71562021-01-01202110.1155/2021/8214656IL-18: The Forgotten Cytokine in Dengue ImmunopathogenesisJosephine Diony Nanda0Tzong-Shiann Ho1Rahmat Dani Satria2Ming-Kai Jhan3Yung-Ting Wang4Chiou-Feng Lin5International Ph.D. Program in Cell Therapy and Regenerative MedicineDepartment of PediatricsInternational Ph.D. Program in MedicineDepartment of Microbiology and ImmunologyDepartment of Microbiology and ImmunologyInternational Ph.D. Program in Cell Therapy and Regenerative MedicineDengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies.http://dx.doi.org/10.1155/2021/8214656 |
| spellingShingle | Josephine Diony Nanda Tzong-Shiann Ho Rahmat Dani Satria Ming-Kai Jhan Yung-Ting Wang Chiou-Feng Lin IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis Journal of Immunology Research |
| title | IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis |
| title_full | IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis |
| title_fullStr | IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis |
| title_full_unstemmed | IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis |
| title_short | IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis |
| title_sort | il 18 the forgotten cytokine in dengue immunopathogenesis |
| url | http://dx.doi.org/10.1155/2021/8214656 |
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