RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway
Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact mechanisms underlying ER-phagy in the pathogenesis of intervertebral disc degeneration remain largely unclear. In the present study, we demonstrate...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2022-03-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2022024 |
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| _version_ | 1850271415206412288 |
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| author | Luo Rongjin Liang Huaizhen Zhang Weifeng Li Gaocai Zhao Kangcheng Hua Wenbin Song Yu Yang Cao |
| author_facet | Luo Rongjin Liang Huaizhen Zhang Weifeng Li Gaocai Zhao Kangcheng Hua Wenbin Song Yu Yang Cao |
| author_sort | Luo Rongjin |
| collection | DOAJ |
| description | Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact mechanisms underlying ER-phagy in the pathogenesis of intervertebral disc degeneration remain largely unclear. In the present study, we demonstrated that RETREG1-mediated ER-phagy is induced by glucose deprivation (GD) treatment, along with ER stress activation and cell function decline. Importantly, ER-phagy was shown to be crucial for cell survival under GD conditions. Furthermore, ER stress was suggested as an upstream event of ER-phagy upon GD treatment and upregulation of ER-phagy could counteract the ER stress response. Therefore, our findings indicate that RETREG1-mediated ER-phagy activation protects against GD treatment-induced cell injury via modulating ER stress in human nucleus pulposus cells. |
| format | Article |
| id | doaj-art-182faffad82943a2bd1339a3ebcaeb24 |
| institution | OA Journals |
| issn | 1672-9145 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-182faffad82943a2bd1339a3ebcaeb242025-08-20T01:52:15ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452022-03-015452453610.3724/abbs.202202420d259ccRETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathwayLuo Rongjin0Liang Huaizhen1Zhang Weifeng2Li Gaocai3Zhao Kangcheng4Hua Wenbin5Song Yu6Yang Cao7[][][][][][][][]Accumulating evidence indicates that ER-phagy serves as a key adaptive regulatory mechanism in response to various stress conditions. However, the exact mechanisms underlying ER-phagy in the pathogenesis of intervertebral disc degeneration remain largely unclear. In the present study, we demonstrated that RETREG1-mediated ER-phagy is induced by glucose deprivation (GD) treatment, along with ER stress activation and cell function decline. Importantly, ER-phagy was shown to be crucial for cell survival under GD conditions. Furthermore, ER stress was suggested as an upstream event of ER-phagy upon GD treatment and upregulation of ER-phagy could counteract the ER stress response. Therefore, our findings indicate that RETREG1-mediated ER-phagy activation protects against GD treatment-induced cell injury via modulating ER stress in human nucleus pulposus cells.https://www.sciengine.com/doi/10.3724/abbs.2022024intervertebral disc degenerationsenescenceapoptosisER-phagyER stress |
| spellingShingle | Luo Rongjin Liang Huaizhen Zhang Weifeng Li Gaocai Zhao Kangcheng Hua Wenbin Song Yu Yang Cao RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway Acta Biochimica et Biophysica Sinica intervertebral disc degeneration senescence apoptosis ER-phagy ER stress |
| title | RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway |
| title_full | RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway |
| title_fullStr | RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway |
| title_full_unstemmed | RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway |
| title_short | RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway |
| title_sort | retreg1 mediated er phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via er stress pathway |
| topic | intervertebral disc degeneration senescence apoptosis ER-phagy ER stress |
| url | https://www.sciengine.com/doi/10.3724/abbs.2022024 |
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