Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders?
In the intricate realm of interactions between hosts and pathogens, Toll-like receptors (TLRs), which play a crucial role in the innate immune response, possess the ability to identify specific molecular signatures. This includes components originating from pathogens such as SARS-CoV-2, as well as t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1458281/full |
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| author | Senthil Kumaran Satyanarayanan Tsz Fung Yip Zixu Han Huachen Zhu Dajiang Qin Dajiang Qin Dajiang Qin Suki Man Yan Lee Suki Man Yan Lee Suki Man Yan Lee |
| author_facet | Senthil Kumaran Satyanarayanan Tsz Fung Yip Zixu Han Huachen Zhu Dajiang Qin Dajiang Qin Dajiang Qin Suki Man Yan Lee Suki Man Yan Lee Suki Man Yan Lee |
| author_sort | Senthil Kumaran Satyanarayanan |
| collection | DOAJ |
| description | In the intricate realm of interactions between hosts and pathogens, Toll-like receptors (TLRs), which play a crucial role in the innate immune response, possess the ability to identify specific molecular signatures. This includes components originating from pathogens such as SARS-CoV-2, as well as the resulting damage-associated molecular patterns (DAMPs), the endogenous molecules released after cellular damage. A developing perspective suggests that TLRs play a central role in neuroinflammation, a fundamental factor in neurodegenerative conditions like Alzheimer’s and Parkinson’s disease (PD). This comprehensive review consolidates current research investigating the potential interplay between TLRs, their signaling mechanisms, and the processes of neurodegeneration following SARS-CoV-2 infection with an aim to elucidate the involvement of TLRs in the long-term neurological complications of COVID-19 and explore the potential of targeting TLRs as a means of implementing intervention strategies for the prevention or treatment of COVID-19-associated long-term brain outcomes. |
| format | Article |
| id | doaj-art-1820100875c44becbb994ddc3de9fc51 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-1820100875c44becbb994ddc3de9fc512025-08-20T03:40:21ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-03-011210.3389/fmed.2025.14582811458281Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders?Senthil Kumaran Satyanarayanan0Tsz Fung Yip1Zixu Han2Huachen Zhu3Dajiang Qin4Dajiang Qin5Dajiang Qin6Suki Man Yan Lee7Suki Man Yan Lee8Suki Man Yan Lee9Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong Science Park, Hong Kong, Hong Kong SAR, ChinaSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong Science Park, Hong Kong, Hong Kong SAR, ChinaSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong Science Park, Hong Kong, Hong Kong SAR, ChinaKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaBioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, ChinaCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong Science Park, Hong Kong, Hong Kong SAR, ChinaSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaIn the intricate realm of interactions between hosts and pathogens, Toll-like receptors (TLRs), which play a crucial role in the innate immune response, possess the ability to identify specific molecular signatures. This includes components originating from pathogens such as SARS-CoV-2, as well as the resulting damage-associated molecular patterns (DAMPs), the endogenous molecules released after cellular damage. A developing perspective suggests that TLRs play a central role in neuroinflammation, a fundamental factor in neurodegenerative conditions like Alzheimer’s and Parkinson’s disease (PD). This comprehensive review consolidates current research investigating the potential interplay between TLRs, their signaling mechanisms, and the processes of neurodegeneration following SARS-CoV-2 infection with an aim to elucidate the involvement of TLRs in the long-term neurological complications of COVID-19 and explore the potential of targeting TLRs as a means of implementing intervention strategies for the prevention or treatment of COVID-19-associated long-term brain outcomes.https://www.frontiersin.org/articles/10.3389/fmed.2025.1458281/fulltoll-like receptors (TLRs)neurodegenerative disorderspost-COVID-19 syndromeneuroinflammationSARS-CoV-2 |
| spellingShingle | Senthil Kumaran Satyanarayanan Tsz Fung Yip Zixu Han Huachen Zhu Dajiang Qin Dajiang Qin Dajiang Qin Suki Man Yan Lee Suki Man Yan Lee Suki Man Yan Lee Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? Frontiers in Medicine toll-like receptors (TLRs) neurodegenerative disorders post-COVID-19 syndrome neuroinflammation SARS-CoV-2 |
| title | Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? |
| title_full | Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? |
| title_fullStr | Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? |
| title_full_unstemmed | Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? |
| title_short | Role of toll-like receptors in post-COVID-19 associated neurodegenerative disorders? |
| title_sort | role of toll like receptors in post covid 19 associated neurodegenerative disorders |
| topic | toll-like receptors (TLRs) neurodegenerative disorders post-COVID-19 syndrome neuroinflammation SARS-CoV-2 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1458281/full |
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