Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance
IntroductionLifestyle factors have demonstrated a significant contribution to resilience against cognitive decline and age-related diseases. However, the understanding of how combinations of modifiable lifestyle behaviors relate to cognitive trajectories across the lifespan remains limited. This stu...
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2025-07-01
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| author | Alba Roca-Ventura Alba Roca-Ventura Alba Roca-Ventura Javier Solana-Sánchez Javier Solana-Sánchez Javier Solana-Sánchez Gabriele Cattaneo Gabriele Cattaneo Gabriele Cattaneo Vanessa Alviarez-Schulze Vanessa Alviarez-Schulze Vanessa Alviarez-Schulze Goretti España-Irla Goretti España-Irla Goretti España-Irla María Redondo-Camós María Redondo-Camós María Redondo-Camós Selma Delgado-Gallén Selma Delgado-Gallén Selma Delgado-Gallén Ruben Romero Ruben Romero Ruben Romero Edgar Buloz-Osorio Edgar Buloz-Osorio Edgar Buloz-Osorio Álvaro Pascual-Leone Álvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz |
| author_facet | Alba Roca-Ventura Alba Roca-Ventura Alba Roca-Ventura Javier Solana-Sánchez Javier Solana-Sánchez Javier Solana-Sánchez Gabriele Cattaneo Gabriele Cattaneo Gabriele Cattaneo Vanessa Alviarez-Schulze Vanessa Alviarez-Schulze Vanessa Alviarez-Schulze Goretti España-Irla Goretti España-Irla Goretti España-Irla María Redondo-Camós María Redondo-Camós María Redondo-Camós Selma Delgado-Gallén Selma Delgado-Gallén Selma Delgado-Gallén Ruben Romero Ruben Romero Ruben Romero Edgar Buloz-Osorio Edgar Buloz-Osorio Edgar Buloz-Osorio Álvaro Pascual-Leone Álvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz |
| author_sort | Alba Roca-Ventura |
| collection | DOAJ |
| description | IntroductionLifestyle factors have demonstrated a significant contribution to resilience against cognitive decline and age-related diseases. However, the understanding of how combinations of modifiable lifestyle behaviors relate to cognitive trajectories across the lifespan remains limited. This study aims to explore the relationship between lifestyle trajectories—including cognitive activity, physical exercise, sleep, socialization, nutrition, alcohol consumption, tobacco use, and body mass index (BMI)—and cognitive performance in healthy middle-aged adults.MethodsData were obtained from the Barcelona Brain Health Initiative (BBHI), an ongoing longitudinal prospective cohort study. Participants completed repeated self-reports on lifestyle factors and underwent in-person neuropsychological assessments. Kml3d clustering was applied to the longitudinal lifestyle data to identify distinct profiles. Cognitive performance was then analyzed across these lifestyle clusters to evaluate associations between lifestyle patterns and cognitive status.ResultsThe results revealed that adherence to healthy lifestyle patterns was strongly associated with better cognitive performance. Specifically, individuals following profiles characterized by higher engagement in cognitive and physical activities, healthier nutrition, better psychological health, and stronger socialization showed superior cognitive status. Moreover, the findings underscored that adhering to a higher number of healthy behaviors had a cumulative positive impact on cognition. Across the studied period—spanning middle age to older adulthood—cognitive trajectories were generally stable.DiscussionThis study highlights that k-means clustering of longitudinal lifestyle data can successfully identify meaningful lifestyle profiles associated with cognitive status in middle-aged adults. The results suggest that specific combinations of modifiable lifestyle factors may exert a more pronounced influence on maintaining cognitive health. These findings provide promising insights for the development and personalization of lifestyle interventions aimed at enhancing brain health and resilience to cognitive decline. |
| format | Article |
| id | doaj-art-18151e3319f74146b03d1a4cdc6424cb |
| institution | DOAJ |
| issn | 1664-1078 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj-art-18151e3319f74146b03d1a4cdc6424cb2025-08-20T02:47:22ZengFrontiers Media S.A.Frontiers in Psychology1664-10782025-07-011610.3389/fpsyg.2025.15109711510971Clustering on longitudinal lifestyle trajectories and their impact on cognitive performanceAlba Roca-Ventura0Alba Roca-Ventura1Alba Roca-Ventura2Javier Solana-Sánchez3Javier Solana-Sánchez4Javier Solana-Sánchez5Gabriele Cattaneo6Gabriele Cattaneo7Gabriele Cattaneo8Vanessa Alviarez-Schulze9Vanessa Alviarez-Schulze10Vanessa Alviarez-Schulze11Goretti España-Irla12Goretti España-Irla13Goretti España-Irla14María Redondo-Camós15María Redondo-Camós16María Redondo-Camós17Selma Delgado-Gallén18Selma Delgado-Gallén19Selma Delgado-Gallén20Ruben Romero21Ruben Romero22Ruben Romero23Edgar Buloz-Osorio24Edgar Buloz-Osorio25Edgar Buloz-Osorio26Álvaro Pascual-Leone27Álvaro Pascual-Leone28David Bartrés-Faz29David Bartrés-Faz30David Bartrés-Faz31Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, i Institut de Neurociències, Universitat de Barcelona, Barcelona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainFundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, SpainUniversitat Autònoma de Barcelona, Bellaterra, SpainHinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, United StatesDepartment of Neurology, Harvard Medical School, Boston, MA, United StatesInstitut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, SpainDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, i Institut de Neurociències, Universitat de Barcelona, Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainIntroductionLifestyle factors have demonstrated a significant contribution to resilience against cognitive decline and age-related diseases. However, the understanding of how combinations of modifiable lifestyle behaviors relate to cognitive trajectories across the lifespan remains limited. This study aims to explore the relationship between lifestyle trajectories—including cognitive activity, physical exercise, sleep, socialization, nutrition, alcohol consumption, tobacco use, and body mass index (BMI)—and cognitive performance in healthy middle-aged adults.MethodsData were obtained from the Barcelona Brain Health Initiative (BBHI), an ongoing longitudinal prospective cohort study. Participants completed repeated self-reports on lifestyle factors and underwent in-person neuropsychological assessments. Kml3d clustering was applied to the longitudinal lifestyle data to identify distinct profiles. Cognitive performance was then analyzed across these lifestyle clusters to evaluate associations between lifestyle patterns and cognitive status.ResultsThe results revealed that adherence to healthy lifestyle patterns was strongly associated with better cognitive performance. Specifically, individuals following profiles characterized by higher engagement in cognitive and physical activities, healthier nutrition, better psychological health, and stronger socialization showed superior cognitive status. Moreover, the findings underscored that adhering to a higher number of healthy behaviors had a cumulative positive impact on cognition. Across the studied period—spanning middle age to older adulthood—cognitive trajectories were generally stable.DiscussionThis study highlights that k-means clustering of longitudinal lifestyle data can successfully identify meaningful lifestyle profiles associated with cognitive status in middle-aged adults. The results suggest that specific combinations of modifiable lifestyle factors may exert a more pronounced influence on maintaining cognitive health. These findings provide promising insights for the development and personalization of lifestyle interventions aimed at enhancing brain health and resilience to cognitive decline.https://www.frontiersin.org/articles/10.3389/fpsyg.2025.1510971/fulllifestyle and behaviorclustering analysisbrain healthlongitudinal analysescognitionneuropsychological assessment |
| spellingShingle | Alba Roca-Ventura Alba Roca-Ventura Alba Roca-Ventura Javier Solana-Sánchez Javier Solana-Sánchez Javier Solana-Sánchez Gabriele Cattaneo Gabriele Cattaneo Gabriele Cattaneo Vanessa Alviarez-Schulze Vanessa Alviarez-Schulze Vanessa Alviarez-Schulze Goretti España-Irla Goretti España-Irla Goretti España-Irla María Redondo-Camós María Redondo-Camós María Redondo-Camós Selma Delgado-Gallén Selma Delgado-Gallén Selma Delgado-Gallén Ruben Romero Ruben Romero Ruben Romero Edgar Buloz-Osorio Edgar Buloz-Osorio Edgar Buloz-Osorio Álvaro Pascual-Leone Álvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance Frontiers in Psychology lifestyle and behavior clustering analysis brain health longitudinal analyses cognition neuropsychological assessment |
| title | Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance |
| title_full | Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance |
| title_fullStr | Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance |
| title_full_unstemmed | Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance |
| title_short | Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance |
| title_sort | clustering on longitudinal lifestyle trajectories and their impact on cognitive performance |
| topic | lifestyle and behavior clustering analysis brain health longitudinal analyses cognition neuropsychological assessment |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2025.1510971/full |
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