Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translation
In eukaryotes, the ribosomal small subunit (40S) is composed of 18S rRNA and 33 ribosomal proteins. 18S rRNA has a special secondary structure and is an indispensable part of the translation process. Herein, a special sequence located in mammalian 18S rRNA named Poly(G)7box, which is composed of sev...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2399310 |
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| author | Dahao Wei Zhangyu Mai Xinan Li Tianli Yu Jiangchao Li |
| author_facet | Dahao Wei Zhangyu Mai Xinan Li Tianli Yu Jiangchao Li |
| author_sort | Dahao Wei |
| collection | DOAJ |
| description | In eukaryotes, the ribosomal small subunit (40S) is composed of 18S rRNA and 33 ribosomal proteins. 18S rRNA has a special secondary structure and is an indispensable part of the translation process. Herein, a special sequence located in mammalian 18S rRNA named Poly(G)7box, which is composed of seven guanines, was found. Poly(G)7 can form a special and stable secondary structure by binding to the translation elongation factor subunit eEF1D and the ribosomal protein RPL32. Poly(G)7box was transfected into cells, and the translation efficiency of cells was inhibited. We believe that Poly(G)7box is an important translation-related functional element located on mammalian 18S rRNA, meanwhile the Poly(G)7 located on mRNA 5’ and 3’ box does not affect mRNA translation. |
| format | Article |
| id | doaj-art-1806f98e5d33452fa060b5be4993cb1a |
| institution | DOAJ |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-1806f98e5d33452fa060b5be4993cb1a2025-08-20T02:50:04ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-0121189090010.1080/15476286.2024.2399310Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translationDahao Wei0Zhangyu Mai1Xinan Li2Tianli Yu3Jiangchao Li4School of Life Sciences and Biopharmaceuticals, Guangdong Pharmaceutical University, Guangzhou, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaLaboratory of Oncology and Immunology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, ChinaLaboratory of Oncology and Immunology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, ChinaLaboratory of Oncology and Immunology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, ChinaIn eukaryotes, the ribosomal small subunit (40S) is composed of 18S rRNA and 33 ribosomal proteins. 18S rRNA has a special secondary structure and is an indispensable part of the translation process. Herein, a special sequence located in mammalian 18S rRNA named Poly(G)7box, which is composed of seven guanines, was found. Poly(G)7 can form a special and stable secondary structure by binding to the translation elongation factor subunit eEF1D and the ribosomal protein RPL32. Poly(G)7box was transfected into cells, and the translation efficiency of cells was inhibited. We believe that Poly(G)7box is an important translation-related functional element located on mammalian 18S rRNA, meanwhile the Poly(G)7 located on mRNA 5’ and 3’ box does not affect mRNA translation.https://www.tandfonline.com/doi/10.1080/15476286.2024.2399310Poly(G)7box18S rRNATranslation regulatory elementsRibosomeConserved sequence |
| spellingShingle | Dahao Wei Zhangyu Mai Xinan Li Tianli Yu Jiangchao Li Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translation RNA Biology Poly(G)7box 18S rRNA Translation regulatory elements Ribosome Conserved sequence |
| title | Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translation |
| title_full | Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translation |
| title_fullStr | Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translation |
| title_full_unstemmed | Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translation |
| title_short | Poly(G)7 box: a functional element of mammalian 18S rRNA involved in translation |
| title_sort | poly g 7 box a functional element of mammalian 18s rrna involved in translation |
| topic | Poly(G)7box 18S rRNA Translation regulatory elements Ribosome Conserved sequence |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2399310 |
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