Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome
ObjectiveTo evaluate efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in treatment of Sjogren’s syndrome (SS).MethodsCNKI, WanFang, VIP, CBM, Sinomed, PubMed, Embase, and Web of Science were searched to collect randomized controlled trials (RCTs) of TCM combin...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1455969/full |
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| author | Xieli Ma Zixia Liu Tian Chang Chuanhui Yao Yuchen Yang Biyue Shang Jiameng Liu Congmin Xia Xun Gong Quan Jiang |
| author_facet | Xieli Ma Zixia Liu Tian Chang Chuanhui Yao Yuchen Yang Biyue Shang Jiameng Liu Congmin Xia Xun Gong Quan Jiang |
| author_sort | Xieli Ma |
| collection | DOAJ |
| description | ObjectiveTo evaluate efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in treatment of Sjogren’s syndrome (SS).MethodsCNKI, WanFang, VIP, CBM, Sinomed, PubMed, Embase, and Web of Science were searched to collect randomized controlled trials (RCTs) of TCM combined with conventional western medicine (CWM) in treating SS from the time of their estalishment to May 2023. The researchers independently screened the literature and extracted data for quality evaluation. Analyses were performed using Review Manager (version 5.4) and R-4.3.1.ResultsA total of 66 RCTs were included, with a sample size of 5,052, involving four kinds of TCM (total glucosides of paeony capsules, tripterygium glycosides tablet, Xinfeng capsule and Jinju Qingrun capsule) and three kinds of CWM(hydroxychloroquine sulfate, Iguratimod and glucocorticoid). The network meta-analysis results showed that IGU + HCQ + TGP ranked the highest in reducing ESR and IgG and improving the Schirmer test when the three drugs were combined. When the two drugs are combined, IGU + GC and TGT + TGP are good choices for reducing erythrocyte sedimentation rate (ESR) and Immunoglobulin G (IgG). Although TGP + HCQ vs. HCQ had the most studies, TGP combined with HCQ did not rank high in each outcome indicator. It is recommended to use TGT and XFG in decreasing ESR and IgG for a single drug. JJQR have an advantageous role in relieving xerostomia and dry eyes.ConclusionTCM combined with CWM has a very significant effect on treating SS compared with CWM alone. According to the network meta-analysis, the best intervention measures of different TCMs for different outcome indicators were obtained.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42023451845]. |
| format | Article |
| id | doaj-art-1802a4def7444ee08b62d9e63f111aba |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-1802a4def7444ee08b62d9e63f111aba2025-08-20T02:05:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-11-011510.3389/fphar.2024.14559691455969Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndromeXieli MaZixia LiuTian ChangChuanhui YaoYuchen YangBiyue ShangJiameng LiuCongmin XiaXun GongQuan JiangObjectiveTo evaluate efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in treatment of Sjogren’s syndrome (SS).MethodsCNKI, WanFang, VIP, CBM, Sinomed, PubMed, Embase, and Web of Science were searched to collect randomized controlled trials (RCTs) of TCM combined with conventional western medicine (CWM) in treating SS from the time of their estalishment to May 2023. The researchers independently screened the literature and extracted data for quality evaluation. Analyses were performed using Review Manager (version 5.4) and R-4.3.1.ResultsA total of 66 RCTs were included, with a sample size of 5,052, involving four kinds of TCM (total glucosides of paeony capsules, tripterygium glycosides tablet, Xinfeng capsule and Jinju Qingrun capsule) and three kinds of CWM(hydroxychloroquine sulfate, Iguratimod and glucocorticoid). The network meta-analysis results showed that IGU + HCQ + TGP ranked the highest in reducing ESR and IgG and improving the Schirmer test when the three drugs were combined. When the two drugs are combined, IGU + GC and TGT + TGP are good choices for reducing erythrocyte sedimentation rate (ESR) and Immunoglobulin G (IgG). Although TGP + HCQ vs. HCQ had the most studies, TGP combined with HCQ did not rank high in each outcome indicator. It is recommended to use TGT and XFG in decreasing ESR and IgG for a single drug. JJQR have an advantageous role in relieving xerostomia and dry eyes.ConclusionTCM combined with CWM has a very significant effect on treating SS compared with CWM alone. According to the network meta-analysis, the best intervention measures of different TCMs for different outcome indicators were obtained.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42023451845].https://www.frontiersin.org/articles/10.3389/fphar.2024.1455969/fullSjogren’s syndromeChinese patent medicinetripterygium wilfordii polyglycosides tabletstotal glucosides of paeony capsulenetwork meta-analysisrandomized controlled |
| spellingShingle | Xieli Ma Zixia Liu Tian Chang Chuanhui Yao Yuchen Yang Biyue Shang Jiameng Liu Congmin Xia Xun Gong Quan Jiang Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome Frontiers in Pharmacology Sjogren’s syndrome Chinese patent medicine tripterygium wilfordii polyglycosides tablets total glucosides of paeony capsule network meta-analysis randomized controlled |
| title | Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome |
| title_full | Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome |
| title_fullStr | Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome |
| title_full_unstemmed | Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome |
| title_short | Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren’s syndrome |
| title_sort | network meta analysis of integrated traditional chinese and western medicine in the treatment of sjogren s syndrome |
| topic | Sjogren’s syndrome Chinese patent medicine tripterygium wilfordii polyglycosides tablets total glucosides of paeony capsule network meta-analysis randomized controlled |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1455969/full |
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